[Behavioral and electroencephalographic effects of delta sleep inducing peptide and its analogue on metaphit-induced audiogenic seizures in rats].

Stanojlović O, Zivanović D, Mirković S, Vucević D

Srpski arhiv za celokupno lekarstvo1 Nov 2004Cited by 2 (Europe PMC)

PMID15938222DOI10.2298/sarh0412421sPepBankPUB-15938222

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with metaphit-induced audiogenic seizures, DSIP significantly increased the power spectra of delta waves.
In plain wordsIn rats with induced seizures, DSIP raised delta wave activity in the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseDelta wave power spectra
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Both DSIP and DSIP1-4 significantly increased the power spectra of d waves and decreased the incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.
Report a problemFND-1593822201
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the incidence of seizures.
In plain wordsIn rats with induced seizures, DSIP lowered how often seizures happened.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseIncidence of metaphit-induced seizures
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Both DSIP and DSIP1-4 significantly increased the power spectra of d waves and decreased the incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.
Report a problemFND-1593822202
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the mean seizure grade.
In plain wordsIn rats with induced seizures, DSIP lowered how severe seizures were.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseMean seizure grade
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Both DSIP and DSIP1-4 significantly increased the power spectra of d waves and decreased the incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.
Report a problemFND-1593822203
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-induced audiogenic seizures, DSIP significantly decreased the tonic component of convulsions.
In plain wordsIn rats with induced seizures, DSIP reduced the tonic (stiffening) part of convulsions.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseTonic component of convulsions
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures
Comparator
Metaphit alone
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Both DSIP and DSIP1-4 significantly increased the power spectra of d waves and decreased the incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of DSIP and its analogue DSIP1-4 on metaphit 1-[1(3-isothiocyanatophenylciclohexyl)-piperidine] induced audiogenic seizures were evaluated in rats.
Report a problemFND-1593822204

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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