Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts.

Kawamura K, Fukuda J, Kumagai J, Shimizu Y, Kodama H, Nakamura A, Tanaka T

Endocrinology2 Jun 2005Cited by 31 (Europe PMC)

PMID15932933DOI10.1210/en.2004-1646PepBankPUB-15932933

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In mouse embryos, ganirelix acetate inhibited development beyond the expanded blastocyst stage.
In plain wordsIn lab tests, ganirelix acetate inhibited mouse embryo development beyond the expanded blastocyst stage.
Peptide
Ganirelix
Outcome
DecreaseDevelopment beyond expanded blastocyst stage
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In contrast, treatment with GnRH-I antagonist, ganirelix acetate, inhibited development of preimplantation embryos beyond the expanded blastocyst stage
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293301
02LabIn vitro (cells)Mechanism
In mouse embryos, ganirelix acetate induced apoptosis.
In plain wordsIn lab tests, ganirelix acetate induced programmed cell death in mouse embryos.
Peptide
Ganirelix
Outcome
IncreaseApoptosis
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In contrast, treatment with GnRH-I antagonist, ganirelix acetate, inhibited development of preimplantation embryos beyond the expanded blastocyst stage and induced apoptosis
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293302
03LabIn vitro (cells)Mechanism
In mouse blastocysts, ganirelix-induced cell death involved disruption of mitochondrial function.
In plain wordsIn lab tests, ganirelix-induced death of mouse blastocyst cells involved disrupted mitochondrial function.
Peptide
Ganirelix
Outcome
Not applicableMitochondrial function disruption
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
GnRH-I antagonist-induced cell death was mediated by disruption of mitochondrial function, release of cytochrome c, and activation of caspase-3.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293303
04LabIn vitro (cells)Mechanism
In mouse blastocysts, ganirelix-induced cell death involved cytochrome c release.
In plain wordsIn lab tests, ganirelix-induced death of mouse blastocyst cells involved cytochrome c release.
Peptide
Ganirelix
Outcome
Not applicableCytochrome c release
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
GnRH-I antagonist-induced cell death was mediated by disruption of mitochondrial function, release of cytochrome c, and activation of caspase-3.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293304
05LabIn vitro (cells)Mechanism
In mouse blastocysts, ganirelix-induced cell death involved caspase-3 activation.
In plain wordsIn lab tests, ganirelix-induced death of mouse blastocyst cells involved caspase-3 activation.
Peptide
Ganirelix
Outcome
Not applicableCaspase-3 activation
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
GnRH-I antagonist-induced cell death was mediated by disruption of mitochondrial function, release of cytochrome c, and activation of caspase-3.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293305
06LabIn vitro (cells)Mechanism
In mouse blastocysts, ganirelix decreased epidermal growth factor expression.
In plain wordsIn lab tests, ganirelix decreased epidermal growth factor expression in mouse blastocysts.
Peptide
Ganirelix
Outcome
DecreaseEpidermal growth factor expression
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, treatment with GnRH-I antagonist decreased expression of two antiapoptotic growth factors, epidermal growth factor and IGF-II, in blastocysts.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293306
07LabIn vitro (cells)Mechanism
In mouse blastocysts, ganirelix decreased IGF-II expression.
In plain wordsIn lab tests, ganirelix decreased IGF-II expression in mouse blastocysts.
Peptide
Ganirelix
Outcome
DecreaseIGF-II expression
Study
mousen: not reported in source
preimplantation embryos and blastocysts
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, treatment with GnRH-I antagonist decreased expression of two antiapoptotic growth factors, epidermal growth factor and IGF-II, in blastocysts.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the molecular mechanisms of GnRH-I in the regulation of early embryonic development in mouse.
Report a problemFND-1593293307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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