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Study · Animal study (in vivo) · rat · 2005

2 results

The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity.

Seeley RJ, Burklow ML, Wilmer KA, Matthews CC, Reizes O, McOsker CC, Trokhan DP, Gross MC, Sheldon RJ

Endocrinology2 Jun 2005Cited by 23 (Europe PMC)

PMID15932932 (opens in a new tab)DOI10.1210/en.2004-1663 (opens in a new tab)PepBankPUB-15932932
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In dietary-induced obese rats, MT-II-treated rats that had been food restricted ate significantly more calories than MT-II-treated rats given ad libitum access to food.

    In plain wordsIn obese rats given MT-II, those that had been food restricted ate more calories than those that had free access to food.

    Peptide
    Melanotan II
    Outcome
    IncreaseCaloric intake in food-restricted versus ad libitum rats treated with MT-II
    Study

    ratn: not reported in source

    Dietary-induced obese rats
    Comparator
    MT-II-treated rats with ad libitum access to food
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · osmotic minipump · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    The results show that in food-restricted rats, MT-II-treated rats consume significantly more calories than those receiving MT-II after ad libitum access to food.
    1 context sentence
    Summary · context
    To investigate this, we compared the effect of various doses of MT-II given via osmotic minipump for 28 d to alter food intake, body weight, and body fat in dietary-induced obese rats. In addition, before the implantation of the minipump, dietary-induced obese rats were weight reduced by differing a…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In dietary-induced obese rats, body fat at the end of the study depended on the MT-II dose, and MT-II-treated rats had less body fat than vehicle-treated rats.

    In plain wordsIn obese rats, MT-II led to less body fat than vehicle, and the amount depended on the dose.

    Peptide
    Melanotan II
    Outcome
    DecreaseFinal body fat
    Study

    ratn: not reported in source

    Dietary-induced obese rats
    Comparator
    Vehicle-treated rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · osmotic minipump · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    More importantly, regardless of the widely differing levels of body fat among the different dietary treatments employed, body fat at the end of the study was determined exclusively by the dose of MT-II, with MT-II-treated rats having less body fat than vehicle-treated rats.
    1 context sentence
    Summary · context
    To investigate this, we compared the effect of various doses of MT-II given via osmotic minipump for 28 d to alter food intake, body weight, and body fat in dietary-induced obese rats. In addition, before the implantation of the minipump, dietary-induced obese rats were weight reduced by differing a…

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Version history

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  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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