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Study · Not a test of the peptide alone · 2005

3 results

Central responsiveness to a ghrelin mimetic (GHRP-6) is rapidly altered by acute changes in nutritional status in rats.

Tung YC, Hewson AK, Carter RN, Dickson SL

Journal of neuroendocrinology1 Jun 2005Cited by 18 (Europe PMC)

PMID15929744 (opens in a new tab)DOI10.1111/j.1365-2826.2005.01316.x (opens in a new tab)PepBankPUB-15929744
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats after fasting, chow refeeding reversed the potentiated hypothalamic Fos response to GHRP‑6.

    In plain wordsIn rats, chow refeeding reduced the enhanced brain response to GHRP‑6 compared with fasting.

    Peptide
    GHRP-6
    Outcome
    DecreaseFos response after chow refeeding
    Study

    ratn: not reported in source

    Fasted and refed rats challenged with GHRP-6
    Comparator
    Fasted rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In the present study, we show that refeeding with normal rat chow for only 2 h at the end of a 48-h fast reversed the potentiation of the Fos response to GHRP-6 observed in fasted rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats after fasting, sugar refeeding reduced the potentiated Fos response to GHRP‑6.

    In plain wordsIn rats, sugar refeeding reduced the enhanced brain response to GHRP‑6 compared with fasting.

    Peptide
    GHRP-6
    Outcome
    DecreaseFos response after sugar refeeding
    Study

    ratn: not reported in source

    Fasted and refed rats challenged with GHRP-6
    Comparator
    Fasted rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Refeeding with sugar alone for 2 h at the end of a 48-h fast also reduced the potentiated Fos response in fasting, indicating that elevated blood glucose can influence the central responsiveness to ghrelin/GHS.
    1 context sentence
    Summary · context
    In the present study, we show that refeeding with normal rat chow for only 2 h at the end of a 48-h fast reversed the potentiation of the Fos response to GHRP-6 observed in fasted rats.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, PYY(3-36) infusion did not alter central responsiveness to GHRP‑6.

    In plain wordsIn rats, PYY infusion did not change the brain response to GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    Direction not reportedCentral responsiveness after PYY infusion
    Study

    ratn: not reported in source

    Fasted and refed rats challenged with GHRP-6
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    By contrast, infusion of the ileal satiety factor, PYY(3-36) (known to increase postprandially) did not alter the central responsiveness to GHRP-6, although it suppressed feeding and body weight as expected.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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