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Study · In vitro (cells) · rat · 2001

3 results

[Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen].

Brodskiĭ VIa, Khavinson VKh, Zolotarev IuA, Nechaeva NV, Malinin VV, Novikova TE, Gvazava IG, Fateeva VI

Izvestiia Akademii nauk. Seriia biologicheskaia1 Sept 2001Cited by 1 (Europe PMC)

PMID15926314 (opens in a new tab)DOI10.1023/a:1016797124500 (opens in a new tab)PepBankPUB-15926314
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured rat hepatocytes, epitalon did not change the intensity of protein synthesis.

    In plain wordsIn cells, epitalon did not change protein synthesis in rat liver cells.

    Peptide
    Epitalon
    Outcome
    No significant changeProtein synthesis intensity in cultured hepatocytes
    Study

    ratn: not reported in source

    monolayer culture of rat hepatocytes
    Outcome group
    Metabolic pathways and metabolomics · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptide epitalon (Ala-Glu-Asp-Gly) constructed on the basis of analysis of the epiphysis peptides did not change the intensity of protein synthesis in the cultured hepatocytes.
    1 context sentence
    Summary · context
    The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured rat hepatocytes, Livagen increased protein synthesis across ages, with the greatest effect in cells from old animals.

    In plain wordsIn cells from rats of different ages, Livagen increased protein synthesis, with the greatest effect in old animals' cells.

    Peptide
    Livagen (KEDA)
    Outcome
    IncreaseHepatocyte protein synthesis
    Study

    ratn: not reported in source

    Monolayer cultures of rat hepatocytes
    Outcome group
    Protein and amino acid metabolism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptide lyvagen (Lys-Glu-Asp-Ala) obtained by directed chemical synthesis on the basis of amino acid analysis of the liver polypeptide preparations increased the level of protein synthesis in the hepatocytes from rats of different ages; the highest effect was observed in the cells of old animals.
    1 context sentence
    Summary · context
    The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured hepatocytes from old rats, Livagen increased the amplitude of protein synthesis fluctuations.

    In plain wordsIn cells from old rats, Livagen increased the amplitude of protein synthesis fluctuations.

    Peptide
    Livagen (KEDA)
    Outcome
    IncreaseAmplitude of protein synthesis fluctuations in old hepatocytes
    Study

    ratn: not reported in source

    Monolayer cultures of rat hepatocytes
    Outcome group
    Protein and amino acid metabolism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, lyvagen increased the amplitude of protein synthesis fluctuations.
    1 context sentence
    Summary · context
    The circumhoralian rhythm of protein synthesis was determined in a monolayer culture of hepatocytes from rats at the age of 1 to 24 months and weighing from 45 to 480 g, respectively.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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