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Study · Measured the body's own peptide · 2005

3 results

Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats.

Pereira PA, Cardoso A, Paula-Barbosa MM

Brain research1 Jun 2005Cited by 16 (Europe PMC)

PMID15921660 (opens in a new tab)DOI10.1016/j.brainres.2005.04.066 (opens in a new tab)PepBankPUB-15921660
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In aged rats, the number of VIP-immunoreactive neurons in the suprachiasmatic nucleus was strikingly reduced.

    In plain wordsIn old rats, fewer brain clock cells made the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseNumber of VIP-immunoreactive SCN neurons in aged rats
    Study

    ratn: not reported in source

    suprachiasmatic nucleus of aged rats
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    a striking reduction in the number of VP- and VIP-immunoreactive neurons was detected in aged animals
    1 context sentence
    Summary · context
    For this purpose, NGF was delivered intraventricularly to aged rats over a period of 14 days.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In aged rats, intraventricular nerve growth factor completely restored the number of VIP-immunoreactive neurons in the suprachiasmatic nucleus.

    In plain wordsIn old rats, nerve growth factor brought back the number of brain clock cells that make the body's own VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseEffect of NGF on VIP-immunoreactive SCN neuron number in aged rats
    Study

    ratn: not reported in source

    suprachiasmatic nucleus of aged rats
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    found to be completely retrieved by NGF.
    1 context sentence
    Summary · context
    For this purpose, NGF was delivered intraventricularly to aged rats over a period of 14 days.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In aged rats, the volume of suprachiasmatic nucleus neuronal cell bodies did not show age-related variation.

    In plain wordsIn old rats, the size of the brain clock cells that make the body's own VIP did not change with age.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeNeuronal cell body volume in aged rats
    Study

    ratn: not reported in source

    suprachiasmatic nucleus of aged rats
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    No age-related variations were found regarding the volume of the neuronal cell bodies.
    1 context sentence
    Summary · context
    For this purpose, NGF was delivered intraventricularly to aged rats over a period of 14 days.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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