Vasoactive intestinal peptide ameliorates synovial cell functions of collagen-induced arthritis rats by down-regulating NF-kappaB activity.

Yin H, Cheng H, Yu M, Zhang F, Lin J, Gao Y, Han B, Zhu L

Immunological investigations1 Jan 2005Cited by 13 (Europe PMC)

PMID15921157DOI10.1081/imm-55809PepBankPUB-15921157

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cultured synovial cells from rats with collagen-induced arthritis, VIP decreased proliferation.
In plain wordsIn lab-grown joint cells from arthritic rats, VIP reduced cell growth.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSynovial cell proliferation
Study
ratn: not reported in source
synovial cells from collagen-induced arthritis (CIA) rats
Outcome group
Bone and joint · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
decreasing proliferation
1 context sentence(design, population, supporting numbers)
Summary · context
CIA was induced using female Wistar rats by native bovine type II collagen (C II) emulsified with complete Freund's adjuvant (CFA).
Report a problemFND-1592115701
02LabIn vitro (cells)Activity measurement
In cultured synovial cells from rats with collagen-induced arthritis, VIP induced apoptosis.
In plain wordsIn lab-grown joint cells from arthritic rats, VIP caused more cells to die by programmed cell death.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseSynovial cell apoptosis
Study
ratn: not reported in source
synovial cells from collagen-induced arthritis (CIA) rats
Outcome group
Bone and joint · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
inducing apoptosis
1 context sentence(design, population, supporting numbers)
Summary · context
CIA was induced using female Wistar rats by native bovine type II collagen (C II) emulsified with complete Freund's adjuvant (CFA).
Report a problemFND-1592115702
03LabIn vitro (cells)Activity measurement
In cultured synovial cells from rats with collagen-induced arthritis, VIP down-regulated mRNA expression of several inflammatory factors.
In plain wordsIn lab-grown joint cells from arthritic rats, VIP lowered the activity of several inflammation genes.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreasemRNA expression of inflammatory factors
Study
ratn: not reported in source
synovial cells from collagen-induced arthritis (CIA) rats
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
down-regulating mRNA expression of several inflammatory factors.
1 context sentence(design, population, supporting numbers)
Summary · context
CIA was induced using female Wistar rats by native bovine type II collagen (C II) emulsified with complete Freund's adjuvant (CFA).
Report a problemFND-1592115703
04LabIn vitro (cells)Mechanism
In cultured synovial cells from rats with collagen-induced arthritis, VIP down-regulated the activity and expression of NF-kappaB.
In plain wordsIn lab-grown joint cells from arthritic rats, VIP reduced the activity of NF-kappaB, an inflammation switch.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseNF-kappaB activity and expression
Study
ratn: not reported in source
synovial cells from collagen-induced arthritis (CIA) rats
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
VIP was found to play immuno-regulating roles through the down-regulation of the activity and expression of NF-kappaB
1 context sentence(design, population, supporting numbers)
Summary · context
CIA was induced using female Wistar rats by native bovine type II collagen (C II) emulsified with complete Freund's adjuvant (CFA).
Report a problemFND-1592115704
05LabIn vitro (cells)Mechanism
In cultured synovial cells from rats with collagen-induced arthritis, blockade of the VIP receptor counteracted all the effects of VIP.
In plain wordsIn lab-grown joint cells from arthritic rats, blocking the VIP receptor cancelled the effects of VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableEffect of VIP receptor blockade on VIP effects
Study
ratn: not reported in source
synovial cells from collagen-induced arthritis (CIA) rats
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
whereas VIP receptor blockade was found to counteract all the effects.
1 context sentence(design, population, supporting numbers)
Summary · context
CIA was induced using female Wistar rats by native bovine type II collagen (C II) emulsified with complete Freund's adjuvant (CFA).
Report a problemFND-1592115705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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