Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats.

Stanojlović OP, Zivanović DP, Mirković SD, Mikhaleva II

Seizure1 Jun 2005Cited by 4 (Europe PMC)

PMID15911358DOI10.1016/j.seizure.2005.02.001PepBankPUB-15911358

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-provoked seizures, DSIP significantly increased the delta frequency band of the EEG.
In plain wordsIn rats with induced seizures, DSIP increased delta brain-wave activity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseEEG delta frequency band
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures in adult male Wistar albino rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.
2 context sentences(design, population, supporting numbers)
Summary · context
We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats.
Summary · context
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively.
Report a problemFND-1591135801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-provoked seizures, DSIP significantly increased the theta frequency band of the EEG.
In plain wordsIn rats with induced seizures, DSIP increased theta brain-wave activity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseEEG theta frequency band
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures in adult male Wistar albino rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.
2 context sentences(design, population, supporting numbers)
Summary · context
We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats.
Summary · context
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively.
Report a problemFND-1591135802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-provoked seizures, DSIP significantly decreased the incidence of convulsions.
In plain wordsIn rats with induced seizures, DSIP lowered how often seizures happened.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseIncidence of metaphit seizures
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures in adult male Wistar albino rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.
2 context sentences(design, population, supporting numbers)
Summary · context
We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats.
Summary · context
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively.
Report a problemFND-1591135803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-provoked seizures, DSIP significantly decreased the mean seizure grade.
In plain wordsIn rats with induced seizures, DSIP lowered seizure severity.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseMean seizure grade
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures in adult male Wistar albino rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.
2 context sentences(design, population, supporting numbers)
Summary · context
We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats.
Summary · context
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively.
Report a problemFND-1591135804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with metaphit-provoked seizures, DSIP significantly decreased the duration of convulsions.
In plain wordsIn rats with induced seizures, DSIP shortened seizures.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseDuration of metaphit convulsions
Study
ratn: not reported in source
Metaphit-induced audiogenic seizures in adult male Wistar albino rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
DSIP and DSIP-12 significantly (*P<0.05 and **P<0.01) increased in delta and theta frequency bands and decreased the incidence, mean seizure grade and duration of metaphit convulsions.
2 context sentences(design, population, supporting numbers)
Summary · context
We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats.
Summary · context
The rats divided in four groups received (i.p.): saline; metaphit; metaphit+DSIP; and metaphit+DSIP-12, respectively.
Report a problemFND-1591135805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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