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Study · Animal study (in vivo) · mouse · 2005

9 results

[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].

Anisimov VN, Popovich IG, Zabezhinskiĭ MA, Rozenfel'd SV, Khavinson VKh, Semenchenko AV, Iashin AI

Voprosy onkologii1 Jan 2005Cited by 3 (Europe PMC)

PMID15909815 (opens in a new tab)PepBankPUB-15909815
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In senescence accelerated mice, epitalon did not change body weight.

    In plain wordsIn mice, epitalon did not change body weight.

    Peptide
    Epitalon
    Outcome
    No significant changeBody weight
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    As age advanced, the weight increased whereas food consumption and body temperature did not change.
    3 context sentences
    Summary · context
    Exposure to melatonin or epitalon also failed to influence those indices.
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In senescence accelerated mice, epitalon did not change food consumption.

    In plain wordsIn mice, epitalon did not change how much they ate.

    Peptide
    Epitalon
    Outcome
    No significant changeFood consumption
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    As age advanced, the weight increased whereas food consumption and body temperature did not change.
    3 context sentences
    Summary · context
    Exposure to melatonin or epitalon also failed to influence those indices.
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In senescence accelerated mice, epitalon did not change body temperature.

    In plain wordsIn mice, epitalon did not change body temperature.

    Peptide
    Epitalon
    Outcome
    No significant changeBody temperature
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Aging markers · Whole body
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    As age advanced, the weight increased whereas food consumption and body temperature did not change.
    3 context sentences
    Summary · context
    Exposure to melatonin or epitalon also failed to influence those indices.
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In SAMP-1 and SAMR-1 mice, epitalon prevented the age-related rise in irregular estrous cycles.

    In plain wordsIn mice, epitalon prevented the rise in irregular reproductive cycles that comes with age.

    Peptide
    Epitalon
    Outcome
    DecreaseIrregular estrous cycles
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    As age advanced, the incidence of irregular estrous cycles increased both in SAMP-1 and SAMR-1, whereas the treatment with both melatonin and epitalon prevented such disturbances.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In SAMP-1 mice, epitalon was followed by longer mean survival of the last 10% of survivors.

    In plain wordsIn fast-aging mice, epitalon was followed by longer average survival of the longest-living animals.

    Peptide
    Epitalon
    Outcome
    IncreaseMean survival of the last 10% survivors in SAMP-1
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Mortality · Aging and longevity
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Melatonin or epitalon treatment was followed by longer mean and maximum survival in the 10% of the last survivors among SAMP-1.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In SAMP-1 mice, epitalon was followed by longer maximum survival of the last 10% of survivors.

    In plain wordsIn fast-aging mice, epitalon was followed by longer maximum survival.

    Peptide
    Epitalon
    Outcome
    IncreaseMaximum survival of the last 10% survivors in SAMP-1
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Mortality · Aging and longevity
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Melatonin or epitalon treatment was followed by longer mean and maximum survival in the 10% of the last survivors among SAMP-1.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In SAMP-1 mice, epitalon did not affect tumor frequency.

    In plain wordsIn fast-aging mice, epitalon did not change how often tumors appeared.

    Peptide
    Epitalon
    Outcome
    No significant changeTumor frequency in SAMP-1
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    While melatonin failed to influence tumor incidence or term of detection in SAMP-1, neither did epitalon affect frequency.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In SAMP-1 mice, epitalon was followed by longer survival in tumor-free animals.

    In plain wordsIn fast-aging mice, epitalon was followed by longer survival in animals without tumors.

    Peptide
    Epitalon
    Outcome
    IncreaseSurvival of tumor-free SAMP-1 animals
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Mortality · Aging and longevity
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    While melatonin failed to influence tumor incidence or term of detection in SAMP-1, neither did epitalon affect frequency. However, it was followed by longer survival in tumor-free animals.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In SAMR-1 mice, no link was reported between epitalon treatment and carcinogenesis.

    In plain wordsIn aging-resistant mice, no link was found between epitalon and tumor development.

    Peptide
    Epitalon
    Outcome
    No significant changeCarcinogenesis in SAMR-1
    Study

    mousen: not reported in source

    Senescence accelerated mice SAMP-1 and SAMR-1
    Comparator
    Intact or saline-injected controls
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 mkg/mouse · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    No link between melatonin or epitalon treatment, on the one hand, and carcinogenesis, on the other, was reported in SAMR-1.
    2 context sentences
    Summary · context
    Female senescence accelerated mice SAMP-1. (prone) and SAMR-1 (resistant) were exposed 5 times a week monthly to melatonin (with drinking water 20mg/ml during the night hours) or to s.c. injections of epitalon (Ala-Glu-Asp-Gly) at a single dose 1mkg/mouse.
    Summary · context
    Control mice were intact or exposed to injection of 0.1 ml normal saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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