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Study · Animal study (in vivo) · rat · 2005

9 results

Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.

Depoortere I, De Winter B, Thijs T, De Man J, Pelckmans P, Peeters T

European journal of pharmacology1 May 2005Cited by 105 (Europe PMC)

PMID15890336 (opens in a new tab)DOI10.1016/j.ejphar.2005.04.008 (opens in a new tab)PepBankPUB-15890336
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intraperitoneal GHRP‑6 accelerated gastric emptying; motilin did not.

    In plain wordsIn rats, GHRP‑6 sped up emptying of the stomach, while motilin did not.

    Peptide
    GHRP-6
    Outcome
    IncreaseGastric emptying
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    10-150 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin and GHRP-6 but not motilin accelerated gastric emptying and transit in rats.
    1 context sentence
    Summary · context
    Ghrelin, GHRP-6 or motilin (10-150 microg/kg) were injected i.p. and the effects on gastric emptying and transit were measured after intragastric application of Evans blue.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intraperitoneal GHRP‑6 accelerated gastric transit; motilin did not.

    In plain wordsIn rats, GHRP‑6 sped up movement of food through the stomach, while motilin did not.

    Peptide
    GHRP-6
    Outcome
    IncreaseGastric transit
    Study

    ratn: not reported in source

    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    10-150 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin and GHRP-6 but not motilin accelerated gastric emptying and transit in rats.
    1 context sentence
    Summary · context
    Ghrelin, GHRP-6 or motilin (10-150 microg/kg) were injected i.p. and the effects on gastric emptying and transit were measured after intragastric application of Evans blue.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats, GHRP‑6 was less potent than ghrelin in accelerating gastric emptying and transit.

    In plain wordsIn rats, GHRP‑6 was less potent than ghrelin at speeding up stomach emptying and transit.

    Peptide
    GHRP-6
    Outcome
    Not applicablePotency on gastric emptying and transit relative to ghrelin
    Study

    ratn: not reported in source

    Comparator
    ghrelin
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    10-150 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin was more potent than GHRP-6 and the dose-response relationship for ghrelin but not for GHRP-6 was bell-shaped.
    1 context sentence
    Summary · context
    Ghrelin, GHRP-6 or motilin (10-150 microg/kg) were injected i.p. and the effects on gastric emptying and transit were measured after intragastric application of Evans blue.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, the dose-response relationship of GHRP‑6 on gastric emptying and transit was not bell-shaped, unlike that of ghrelin.

    In plain wordsIn rats, the dose-response curve of GHRP‑6 was not bell-shaped, while the curve of ghrelin was.

    Peptide
    GHRP-6
    Outcome
    Not applicableShape of the dose-response relationship
    Study

    ratn: not reported in source

    Comparator
    ghrelin
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    10-150 microg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin was more potent than GHRP-6 and the dose-response relationship for ghrelin but not for GHRP-6 was bell-shaped.
    1 context sentence
    Summary · context
    Ghrelin, GHRP-6 or motilin (10-150 microg/kg) were injected i.p. and the effects on gastric emptying and transit were measured after intragastric application of Evans blue.
  5. 05LabEx vivo tissueActivity measurement

    In rat fundic strips, GHRP‑6 showed a bell-shaped concentration-response curve for on-responses with a maximal effect at 0.50 microM.

    In plain wordsIn rat stomach muscle strips, the effect of GHRP‑6 on the relaxation response peaked at 0.50 microM.

    Peptide
    GHRP-6
    Outcome
    Not applicableConcentration of maximal effect on on-responses in fundic strips
    Study

    ratn: not reported in source

    fundic muscle strips
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.50 microM · bath applicationAs given in this study (rat).

    Measurements

    Concentration of maximal effect (on-responses)
    0.5 microM
    GHRP-6, fundic strips

    Source sentences

    Summary
    The concentration response curves in muscle strips of the fundus were bell-shaped with maximal effects for ghrelin at 1.2 microM (on-responses) and 0.66 microM (off-responses) and for GHRP-6 at 0.50 microM (on-responses) and 0.26 microM (off-responses).
    1 context sentence
    Summary · context
    In antral and fundic strips the effect of motilin, ghrelin or GHRP-6 was studied during electrical field stimulation (EFS) in the absence and presence of N(G)-nitro-l-arginine methyl ester hydrochloride (l-NAME) (300 microM).
  6. 06LabEx vivo tissueActivity measurement

    In rat fundic strips, GHRP‑6 showed a bell-shaped concentration-response curve for off-responses with a maximal effect at 0.26 microM.

    In plain wordsIn rat stomach muscle strips, the effect of GHRP‑6 on the off-contraction peaked at 0.26 microM.

    Peptide
    GHRP-6
    Outcome
    Not applicableConcentration of maximal effect on off-responses in fundic strips
    Study

    ratn: not reported in source

    fundic muscle strips
    Outcome group
    Gastrointestinal motility · Gastrointestinal
    Studied dose
    0.26 microM · bath applicationAs given in this study (rat).

    Measurements

    Concentration of maximal effect (off-responses)
    0.26 microM
    GHRP-6, fundic strips

    Source sentences

    Summary
    The concentration response curves in muscle strips of the fundus were bell-shaped with maximal effects for ghrelin at 1.2 microM (on-responses) and 0.66 microM (off-responses) and for GHRP-6 at 0.50 microM (on-responses) and 0.26 microM (off-responses).
    1 context sentence
    Summary · context
    In antral and fundic strips the effect of motilin, ghrelin or GHRP-6 was studied during electrical field stimulation (EFS) in the absence and presence of N(G)-nitro-l-arginine methyl ester hydrochloride (l-NAME) (300 microM).

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 07LabNot a test of GHRP-6 aloneEx vivo tissueEfficacy outcome

    In rat fundic strips, ghrelin agonists (ghrelin and GHRP‑6, pooled) reduced neural on-relaxations.

    In plain wordsIn rat stomach muscle strips, the ghrelin-like drugs, pooled, reduced the relaxation response to nerve stimulation.

    Peptide
    GHRP-6
    Outcome
    DecreaseOn-relaxation in fundic strips under electrical field stimulation
    Study

    ratn: not reported in source

    fundic muscle strips
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    Under normal conditions, the ghrelin agonists reduced the on-relaxations in fundic strips and increased the cholinergic off-contractions in antral and fundic strips.
    2 context sentences
    Summary · context
    In antral and fundic strips the effect of motilin, ghrelin or GHRP-6 was studied during electrical field stimulation (EFS) in the absence and presence of N(G)-nitro-l-arginine methyl ester hydrochloride (l-NAME) (300 microM).
    Summary · context
    We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 08LabNot a test of GHRP-6 aloneEx vivo tissueEfficacy outcome

    In rat antral and fundic strips, ghrelin agonists (ghrelin and GHRP‑6, pooled) increased cholinergic off-contractions.

    In plain wordsIn rat stomach muscle strips, the ghrelin-like drugs, pooled, increased the contraction that follows nerve stimulation.

    Peptide
    GHRP-6
    Outcome
    IncreaseCholinergic off-contraction in antral and fundic strips
    Study

    ratn: not reported in source

    antral and fundic muscle strips
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    Under normal conditions, the ghrelin agonists reduced the on-relaxations in fundic strips and increased the cholinergic off-contractions in antral and fundic strips.
    2 context sentences
    Summary · context
    In antral and fundic strips the effect of motilin, ghrelin or GHRP-6 was studied during electrical field stimulation (EFS) in the absence and presence of N(G)-nitro-l-arginine methyl ester hydrochloride (l-NAME) (300 microM).
    Summary · context
    We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 09LabNot a test of GHRP-6 aloneEx vivo tissueMechanism

    In rat gastric strips treated with l-NAME, the effect of ghrelin agonists (ghrelin and GHRP‑6, pooled) on cholinergic excitatory motor responses was confirmed.

    In plain wordsIn rat stomach muscle strips, the ghrelin-like drugs, pooled, still acted on nerve-driven contractions when nitric oxide synthesis was blocked.

    Peptide
    GHRP-6
    Outcome
    Not applicableCholinergic excitatory motor responses with l-NAME
    Study

    ratn: not reported in source

    antral and fundic muscle strips
    Outcome group
    Gastrointestinal motility · Gastrointestinal

    Source sentences

    Summary
    Studies in the presence of l-NAME confirmed the effect of the ghrelin agonists on cholinergic excitatory motor responses.
    2 context sentences
    Summary · context
    In antral and fundic strips the effect of motilin, ghrelin or GHRP-6 was studied during electrical field stimulation (EFS) in the absence and presence of N(G)-nitro-l-arginine methyl ester hydrochloride (l-NAME) (300 microM).
    Summary · context
    We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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