In mouse embryo cultures exposed to ethanol, L-NAP significantly increased the percentage that reached the reported neural fold closure stages.
In plain wordsIn lab tests with mouse embryos exposed to ethanol, L-NAP increased the percentage that reached the reported neural fold closure stages.
- Peptide
- Davunetide
- Outcome
- IncreaseNeural fold closure
- Study
mousen: not reported in source
C57BL/6J whole embryo culture- Comparator
- Ethanol exposure
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 10(-10) M · 6 h exposure followed by 20 h in control mediumAs given in this study (mouse).
Source sentences
Co-incubation with ethanol and L-NAP (all L-amino acids), D-NAP (all D-amino acids) or SAL significantly increased the percentage of embryos that had begun to close their neural folds at the level of the forebrain/midbrain junction or that had progressed beyond this stage of closure.
2 context sentences(design, population, supporting numbers)
Gestational day 8.0 (3-5 somites) C57BL/6J mouse embryos were grown for 6 h in control medium, 100 mM ethanol and 10(-10) M peptides and then maintained for an additional 20 h in control medium.
At the end of the culture period, only embryos having 18-19 somite pairs were examined and compared for the degree of neural tube closure.