Thymosin alpha 1 attenuates lipid peroxidation and improves fructose-induced steatohepatitis in rats.

Armutcu F, Coskun O, Gürel A, Kanter M, Can M, Ucar F, Unalacak M

Clinical biochemistry1 Jun 2005Cited by 68 (Europe PMC)

PMID15885234DOI10.1016/j.clinbiochem.2005.01.013PepBankPUB-15885234

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the raised liver nitric oxide level near the control value.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept liver nitric oxide near normal levels, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
DecreaseLiver nitric oxide level
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In comparison with the C group, the F group had a higher nitric oxide (NO) level, xanthine oxidase (XO) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (TBARS), and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activi…
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the raised liver xanthine oxidase activity near the control value.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept a liver enzyme linked to oxidative stress near normal, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
DecreaseLiver xanthine oxidase activity
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In comparison with the C group, the F group had a higher nitric oxide (NO) level, xanthine oxidase (XO) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (TBARS), and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activi…
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept liver lipid peroxidation (TBARS) near the control value.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept liver fat damage markers near normal, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
DecreaseLiver lipid peroxidation (TBARS)
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In comparison with the C group, the F group had a higher nitric oxide (NO) level, xanthine oxidase (XO) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (TBARS), and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activi…
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the lowered liver superoxide dismutase activity near the control value.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept a liver antioxidant enzyme near normal levels, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
IncreaseLiver superoxide dismutase activity
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In comparison with the C group, the F group had a higher nitric oxide (NO) level, xanthine oxidase (XO) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (TBARS), and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activi…
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523404
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the lowered liver glutathione peroxidase activity near the control value.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept a liver antioxidant enzyme near normal levels, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
IncreaseLiver glutathione peroxidase activity
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Oxidative stress · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In comparison with the C group, the F group had a higher nitric oxide (NO) level, xanthine oxidase (XO) activity, and lipid peroxidation, as indicated by concentrations of thiobarbituric acid reactive substances (TBARS), and lower superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activi…
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523405
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the raised blood IL-1beta level near normal.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept the blood inflammation marker IL-1beta near normal, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
DecreaseBlood IL-1beta level
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In addition, increased IL-1beta and IL-6 levels were kept at near to normal levels with treatment of Talpha(1), but not IL-2 levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523406
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 kept the raised blood IL-6 level near normal.
In plain wordsIn rats fed fructose, thymosin alpha‑1 kept the blood inflammation marker IL-6 near normal, compared with fructose alone.
Peptide
Thymosin alpha-1
Outcome
DecreaseBlood IL-6 level
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In addition, increased IL-1beta and IL-6 levels were kept at near to normal levels with treatment of Talpha(1), but not IL-2 levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523407
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 did not bring the blood IL-2 level back to normal.
In plain wordsIn rats fed fructose, thymosin alpha‑1 did not bring the blood marker IL-2 back to normal levels.
Peptide
Thymosin alpha-1
Outcome
No significant changeBlood IL-2 level
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
In addition, increased IL-1beta and IL-6 levels were kept at near to normal levels with treatment of Talpha(1), but not IL-2 levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523408
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with fructose-induced steatosis, thymosin alpha‑1 treatment protected most liver cells, with minimal steatosis in the remaining cells.
In plain wordsIn rats fed fructose, thymosin alpha‑1 protected most liver cells and left little fat build-up in the rest.
Peptide
Thymosin alpha-1
Outcome
DecreaseLiver steatosis histology
Study
ratn: not reported in source
Fructose-induced hepatic steatosis
Comparator
High-fructose diet without Talpha1
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · 10 daysAs given in this study (rat).
Source sentences
Summary
Talpha(1) treatment protected the majority of the liver cells, while minimal macrovesicular and microvesicular steatosis was observed in the remaining cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-four rats at random were divided into three groups (each group containing eight animals); the control group (C), which received a purified diet; the high-fructose-fed group (F); and the high-fructose-fed and Talpha(1) injected group (F + T).
Report a problemFND-1588523409

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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