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Study · Animal study (in vivo) · mouse · 2005

7 results

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology5 May 2005Cited by 222 (Europe PMC)

PMID15878932 (opens in a new tab)DOI10.1096/fj.04-3144fje (opens in a new tab)PepBankPUB-15878932
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mouse skeletal muscle, injected AICAR increased PGC-1alpha mRNA.

    In plain wordsIn mice, injected AICAR increased muscle PGC-1alpha mRNA.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha mRNA
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In addition, subcutaneous injection of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) increased the mRNA content of PGC-1alpha, HKII, FOXO1, PDK4, and UCP3,
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mouse skeletal muscle, injected AICAR increased HKII mRNA.

    In plain wordsIn mice, injected AICAR increased muscle HKII mRNA.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHKII mRNA
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In addition, subcutaneous injection of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) increased the mRNA content of PGC-1alpha, HKII, FOXO1, PDK4, and UCP3,
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mouse skeletal muscle, injected AICAR increased FOXO1 mRNA.

    In plain wordsIn mice, injected AICAR increased muscle FOXO1 mRNA.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseFOXO1 mRNA
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In addition, subcutaneous injection of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) increased the mRNA content of PGC-1alpha, HKII, FOXO1, PDK4, and UCP3,
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mouse skeletal muscle, injected AICAR increased PDK4 mRNA.

    In plain wordsIn mice, injected AICAR increased muscle PDK4 mRNA.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePDK4 mRNA
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In addition, subcutaneous injection of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) increased the mRNA content of PGC-1alpha, HKII, FOXO1, PDK4, and UCP3,
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mouse skeletal muscle, injected AICAR increased UCP3 mRNA.

    In plain wordsIn mice, injected AICAR increased muscle UCP3 mRNA.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseUCP3 mRNA
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In addition, subcutaneous injection of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) increased the mRNA content of PGC-1alpha, HKII, FOXO1, PDK4, and UCP3,

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mouse muscle, alpha2-AMPK knockout abolished the AICAR-induced increase in PGC-1alpha mRNA.

    In plain wordsIn mice, alpha2-AMPK gene deletion blocked the muscle PGC-1alpha mRNA increase after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAICAR-induced PGC-1alpha response after alpha2 knockout
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    and alpha2-KO abolished the AICAR-induced increases in PGC-1alpha and HKII mRNA.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mouse muscle, alpha2-AMPK knockout abolished the AICAR-induced increase in HKII mRNA.

    In plain wordsIn mice, alpha2-AMPK gene deletion blocked the muscle HKII mRNA increase after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAICAR-induced HKII response after alpha2 knockout
    Study

    mousen: not reported in source

    mouse skeletal muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    and alpha2-KO abolished the AICAR-induced increases in PGC-1alpha and HKII mRNA.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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