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Study · Animal study (in vivo) · mouse · 2005

10 results

Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone.

Pettway GJ, Schneider A, Koh AJ, Widjaja E, Morris MD, Meganck JA, Goldstein SA, McCauley LK

Bone1 Jun 2005Cited by 61 (Europe PMC)

PMID15878317 (opens in a new tab)DOI10.1016/j.bone.2005.02.015 (opens in a new tab)PepBankPUB-15878317
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, PTH increased marrow cellularity in early ectopic ossicles versus vehicle.

    In plain wordsIn mice, PTH increased marrow cellularity in early ectopic ossicles versus vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMarrow cellularity
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Micro-radiography and histomorphometry revealed increased marrow cellularity in group 1 PTH-treated ossicles, increased bone in group 2 PTH-treated ossicles, and similar amounts of bone in both group 3 and 4 ossicles regardless of treatment.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, PTH increased bone amount in early ectopic ossicles versus vehicle after 3 weeks.

    In plain wordsIn mice, early PTH treatment increased bone amount in ectopic ossicles versus vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone amount after early treatment
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-radiography and histomorphometry revealed increased marrow cellularity in group 1 PTH-treated ossicles, increased bone in group 2 PTH-treated ossicles, and similar amounts of bone in both group 3 and 4 ossicles regardless of treatment.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, bone amounts in ectopic ossicles were similar after prolonged PTH or vehicle treatment.

    In plain wordsIn mice, prolonged PTH treatment produced similar bone amounts in ectopic ossicles as vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone amount after prolonged treatment
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 7 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Micro-radiography and histomorphometry revealed increased marrow cellularity in group 1 PTH-treated ossicles, increased bone in group 2 PTH-treated ossicles, and similar amounts of bone in both group 3 and 4 ossicles regardless of treatment.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, delayed PTH treatment produced similar bone amounts in ectopic ossicles as vehicle.

    In plain wordsIn mice, delayed PTH treatment produced similar bone amounts in ectopic ossicles as vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone amount after delayed treatment
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 3 weeks initiated 12 weeks after implantationAs given in this study (mouse).

    Source sentences

    Summary
    Micro-radiography and histomorphometry revealed increased marrow cellularity in group 1 PTH-treated ossicles, increased bone in group 2 PTH-treated ossicles, and similar amounts of bone in both group 3 and 4 ossicles regardless of treatment.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, phosphate mineral incidence did not differ between PTH- and vehicle-treated ossicles.

    In plain wordsIn mice, phosphate mineral incidence did not differ between PTH- and vehicle-treated ossicles.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePhosphate mineral incidence
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incidence of phosphate mineral and phosphate mineral to hydroxyproline ratio via Raman spectroscopy were significantly higher after 3 weeks versus 1 week of PTH treatment, but there was no difference between PTH- and vehicle-treated ossicles.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, phosphate mineral to hydroxyproline ratio did not differ between PTH- and vehicle-treated ossicles.

    In plain wordsIn mice, phosphate mineral to hydroxyproline ratio did not differ between PTH- and vehicle-treated ossicles.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePhosphate mineral to hydroxyproline ratio
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incidence of phosphate mineral and phosphate mineral to hydroxyproline ratio via Raman spectroscopy were significantly higher after 3 weeks versus 1 week of PTH treatment, but there was no difference between PTH- and vehicle-treated ossicles.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In nude mice, intermittent PTH increased osteocalcin mRNA in ossicles after 1 week.

    In plain wordsIn mice, intermittent PTH increased osteocalcin gene activity in ossicles compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteocalcin mRNA in ossicles
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Osteocalcin (OC) mRNA was increased after 1 week of intermittent PTH treatment in ossicles and calvaria but an acute injection did not alter OC mRNA.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In nude mice, intermittent PTH increased osteocalcin mRNA in calvaria after 1 week.

    In plain wordsIn mice, intermittent PTH increased osteocalcin gene activity in skull bones compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteocalcin mRNA in calvaria
    Study

    mousen: not reported in source

    Calvaria in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Osteocalcin (OC) mRNA was increased after 1 week of intermittent PTH treatment in ossicles and calvaria but an acute injection did not alter OC mRNA.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In nude mice, an acute PTH injection did not alter osteocalcin mRNA.

    In plain wordsIn mice, an acute PTH injection did not change osteocalcin gene activity compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeOsteocalcin mRNA after acute injection
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Osteocalcin (OC) mRNA was increased after 1 week of intermittent PTH treatment in ossicles and calvaria but an acute injection did not alter OC mRNA.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In nude mice, a single PTH injection increased MGP mRNA in 2-week-old ossicles.

    In plain wordsIn mice, a single PTH injection increased MGP gene activity in two-week-old ossicles compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMGP mRNA after acute injection
    Study

    mousen: not reported in source

    BMSC-derived ectopic ossicles in nude mice
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, a single injection of PTH increased matrix gamma-carboxyglutamic acid protein (MGP) mRNA in 2-week-old ossicles.
    3 context sentences
    Summary · context
    Ectopic ossicles containing cortical bone, trabecular bone, and a hematopoietic marrow were generated from implanted bone marrow stromal cells (BMSC).
    Summary · context
    One week after implantation, nude mice were administered PTH or vehicle for 1 week (group 1), 3 weeks (group 2), or 7 weeks (group 3).
    Summary · context
    Another group was also treated for 3 weeks, initiated 12 weeks after implantation (group 4).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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