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Study · In vitro (cells) · 2005

3 results

Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide stimulate interleukin-6 production in prostate cancer cells and prostatic epithelial cells.

Nagakawa O, Junicho A, Akashi T, Koizumi K, Matsuda T, Fuse H, Saiki I

Oncology reports1 Jun 2005Cited by 6 (Europe PMC)

PMID15870945 (opens in a new tab)DOI10.3892/or.13.6.1217 (opens in a new tab)PepBankPUB-15870945
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In DU-145/AR prostate cancer cells, VIP stimulated interleukin-6 production.

    In plain wordsIn lab-grown prostate cancer cells, VIP increased the production of the inflammatory protein IL-6.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseIL-6 production in DU-145/AR prostate cancer cells
    Study

    humann: not reported in source

    DU-145/AR human prostate cancer cells
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP stimulated the production of IL-6 in DU-145/AR prostate cancer and PrEC cells.
    1 context sentence
    Summary · context
    We performed RT-PCR analysis to assess the expression of VIP receptor (VPAC1, VPAC2 and PAC1) mRNA in normal prostate epithelial and stromal cells and prostate cancer cells, and investigated the effect of VIP and PACAP on the production of IL-6.
  2. 02LabIn vitro (cells)Activity measurement

    In PrEC normal prostate epithelial cells, VIP stimulated interleukin-6 production.

    In plain wordsIn lab-grown normal prostate cells, VIP increased the production of the inflammatory protein IL-6.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseIL-6 production in PrEC prostate epithelial cells
    Study

    humann: not reported in source

    PrEC human prostate epithelial cells
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP stimulated the production of IL-6 in DU-145/AR prostate cancer and PrEC cells.
    1 context sentence
    Summary · context
    We performed RT-PCR analysis to assess the expression of VIP receptor (VPAC1, VPAC2 and PAC1) mRNA in normal prostate epithelial and stromal cells and prostate cancer cells, and investigated the effect of VIP and PACAP on the production of IL-6.
  3. 03LabIn vitro (cells)Mechanism

    In DU-145/AR prostate cancer cells, VIP stimulated IL-6 promoter transcriptional activity.

    In plain wordsIn lab-grown prostate cancer cells, VIP switched on the gene control region for IL-6.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseIL-6 promoter transcriptional activity in DU-145/AR cells
    Study

    humann: not reported in source

    DU-145/AR human prostate cancer cells
    Outcome group
    Inflammation markers · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP stimulated IL-6 promoter transcriptional activity in DU-145/AR cells.
    1 context sentence
    Summary · context
    We performed RT-PCR analysis to assess the expression of VIP receptor (VPAC1, VPAC2 and PAC1) mRNA in normal prostate epithelial and stromal cells and prostate cancer cells, and investigated the effect of VIP and PACAP on the production of IL-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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