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Study · Animal study (in vivo) · mouse · 2005

2 results

Acute depletion of murine primordial follicle reserve by gonadotropin-releasing hormone antagonists.

Danforth DR, Arbogast LK, Friedman CI

Fertility and sterility1 May 2005Cited by 55 (Europe PMC)

PMID15866565 (opens in a new tab)DOI10.1016/j.fertnstert.2004.12.030 (opens in a new tab)PepBankPUB-15866565
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In mice, systemic cetrorelix significantly increased primordial follicle destruction compared with controls.

    In plain wordsIn mice, systemic cetrorelix destroyed more primordial follicles than control treatment.

    Peptide
    Cetrorelix
    Outcome
    IncreasePrimordial follicle destruction after systemic treatment
    Study

    mousen: not reported in source

    Adult C57Bl/6 mice
    Comparator
    Control mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · systemic injectionAs given in this study (mouse).

    Source sentences

    Summary
    Systemic administration of both GnRH antagonists caused a significant destruction of primordial follicles compared with control mice.
    3 context sentences
    Summary · context
    Adult C57Bl/6 mice (5 to 6 weeks old).
    Summary · context
    Mice received either a single injection of GnRH agonist (leuprolide acetate) on study day -10 or injections of the GnRH antagonist (antide or cetrorelix) on study days -3 and 0.
    Summary · context
    To examine direct vs. indirect effects, some mice received GnRH antagonist under the bursa of one ovary, with the contralateral ovary receiving vehicle.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In mice, ovarian cetrorelix produced primordial follicle destruction similar to systemic administration.

    In plain wordsIn mice, cetrorelix applied to the ovary caused follicle destruction similar to systemic treatment.

    Peptide
    Cetrorelix
    Outcome
    Direction not reportedPrimordial follicle destruction after local versus systemic treatment
    Study

    mousen: not reported in source

    Adult C57Bl/6 mice
    Comparator
    Systemic antagonist administration
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · Under the ovarian bursaAs given in this study (mouse).

    Source sentences

    Summary
    Similar results were obtained whether the antagonists were administered systemically or directly to the ovary.
    4 context sentences
    Summary · context
    Systemic administration of both GnRH antagonists caused a significant destruction of primordial follicles compared with control mice.
    Summary · context
    Adult C57Bl/6 mice (5 to 6 weeks old).
    Summary · context
    Mice received either a single injection of GnRH agonist (leuprolide acetate) on study day -10 or injections of the GnRH antagonist (antide or cetrorelix) on study days -3 and 0.
    Summary · context
    To examine direct vs. indirect effects, some mice received GnRH antagonist under the bursa of one ovary, with the contralateral ovary receiving vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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