Skip to content

Study · Not a test of the peptide alone · 2005

3 results

Construction, expression and characterization of human interferon alpha2b-(G4S)n-thymosin alpha1 fusion proteins in Pichia pastoris.

Yang YF, Yuan HY, Liu NS, Chen XL, Gao BY, Lu H, Li YY

World journal of gastroenterology1 May 2005Cited by 8 (Europe PMC)

PMID15849818 (opens in a new tab)PMCIDPMC4305750 (opens in a new tab)DOI10.3748/wjg.v11.i17.2597 (opens in a new tab)PepBankPUB-15849818
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 01LabNot a test of Thymosin alpha-1 aloneEx vivo tissueActivity measurement

    In the E-rosette assay, purified IFNalpha2b-(G4S)n-thymosin alpha1 fusion proteins increased the percentage of E-rosette-forming cells.

    In plain wordsIn lab tests, fusion proteins of interferon alpha2b and thymosin alpha1 raised the share of E-rosette-forming cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseE-rosette-forming cell percentage
    Study

    n: not reported in source

    Pichia pastoris-expressed fusion proteins
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    can enhance the percentage of E-rosette-forming-cell in E-rosette assay.
    2 context sentences
    Summary · context
    For developing a fusion protein drug, fusion proteins of IFNalpha2b and Talpha1 linked by different lengths of (G4S)n (n = 1-3) were constructed and expressed in Pichia pastoris.
    Summary · context
    Antiviral and E-rosette assays were used to investigate the bioactivities of these fusion proteins.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 02LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Activity measurement

    In in vitro antiviral assays, purified IFNalpha2b-(G4S)n-thymosin alpha1 fusion proteins (n = 1-3) showed antiviral activity.

    In plain wordsIn lab tests, fusion proteins of interferon alpha2b and thymosin alpha1 showed antiviral activity.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableAntiviral activity of fusion proteins
    Study

    n: not reported in source

    Pichia pastoris-expressed fusion proteins
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    The purified fusion proteins exhibit antiviral activity
    2 context sentences
    Summary · context
    For developing a fusion protein drug, fusion proteins of IFNalpha2b and Talpha1 linked by different lengths of (G4S)n (n = 1-3) were constructed and expressed in Pichia pastoris.
    Summary · context
    Antiviral and E-rosette assays were used to investigate the bioactivities of these fusion proteins.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 03LabNot a test of Thymosin alpha-1 aloneIn vitro (cell-free)Other

    On SDS-PAGE, the three IFNalpha2b-(G4S)n-thymosin alpha1 fusion proteins had molecular weights of 23.2, 22.9 and 22.6 ku.

    In plain wordsIn lab tests, the three fusion proteins had sizes of 23.2, 22.9 and 22.6 ku.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableMolecular weight of fusion proteins on SDS-PAGE
    Study

    n: not reported in source

    Pichia pastoris-expressed fusion proteins
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    molecular weight
    23.2 ku
    n = 1
    molecular weight
    22.9 ku
    n = 2
    molecular weight
    22.6 ku
    n = 3

    Source sentences

    Summary
    The fusion proteins could be observed on sodium dodecylsulfate-polyacrylamide gel electrophoresis with molecular weight (MW) of 23.2, 22.9, and 22.6 ku, respectively, and reacted to the IFNalpha2b monoclonal antibody and Talpha1 polyclonal antibody.
    2 context sentences
    Summary · context
    For developing a fusion protein drug, fusion proteins of IFNalpha2b and Talpha1 linked by different lengths of (G4S)n (n = 1-3) were constructed and expressed in Pichia pastoris.
    Summary · context
    Antiviral and E-rosette assays were used to investigate the bioactivities of these fusion proteins.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.