Transdermal delivery of human growth hormone through RF-microchannels.

Levin G, Gershonowitz A, Sacks H, Stern M, Sherman A, Rudaev S, Zivin I, Phillip M

Pharmaceutical research7 Apr 2005Cited by 85 (Europe PMC)

PMID15846462DOI10.1007/s11095-005-2498-6PepBankPUB-15846462

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In rats, transdermal hGH through RF-microchannels had 75% bioavailability relative to subcutaneous injection.
In plain wordsIn rats, hGH through skin microchannels had 75% bioavailability compared with injection under the skin.
Peptide
HGH (somatotropin)
Outcome
Not applicableTransdermal hGH bioavailability in rats
Study
ratn: not reported in source
RF-microchannel skin delivery
Comparator
Subcutaneous injection
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · transdermalAs given in this study (rat).
Measurements
Relative bioavailability
75%
rat
Source sentences
Summary
Creation of MCs in the outer layers of the skin enabled efficient delivery of hGH, with a bioavailability of 75% (rats) or 33% (GPs) relative to subcutaneous (s.c.) injection with plasma profiles resembling that of s.c. injection.
2 context sentences(design, population, supporting numbers)
Summary · context
Various doses of hGH in a dry form were applied on rat or guinea pig (GP) skin after the formation of MCs.
Summary · context
The pharmacokinetic profile of systemic hGH in both animal models was monitored for 15 h post patch application.
Report a problemFND-1584646201
02AnimalAnimal study (in vivo)Pharmacokinetics
In guinea pigs, transdermal hGH through RF-microchannels had 33% bioavailability relative to subcutaneous injection.
In plain wordsIn guinea pigs, hGH through skin microchannels had 33% bioavailability compared with injection under the skin.
Peptide
HGH (somatotropin)
Outcome
Not applicableTransdermal hGH bioavailability in guinea pigs
Study
guinea pign: not reported in source
RF-microchannel skin delivery
Comparator
Subcutaneous injection
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · transdermalAs given in this study (guinea pig).
Measurements
Relative bioavailability
33%
guinea pig
Source sentences
Summary
Creation of MCs in the outer layers of the skin enabled efficient delivery of hGH, with a bioavailability of 75% (rats) or 33% (GPs) relative to subcutaneous (s.c.) injection with plasma profiles resembling that of s.c. injection.
2 context sentences(design, population, supporting numbers)
Summary · context
Various doses of hGH in a dry form were applied on rat or guinea pig (GP) skin after the formation of MCs.
Summary · context
The pharmacokinetic profile of systemic hGH in both animal models was monitored for 15 h post patch application.
Report a problemFND-1584646202
03AnimalAnimal study (in vivo)Pharmacokinetics
In rats, transdermal hGH produced plasma profiles resembling those of subcutaneous injection.
In plain wordsIn rats, hGH through skin microchannels produced blood profiles resembling injection under the skin.
Peptide
HGH (somatotropin)
Outcome
Not applicablePlasma hGH profiles in rats
Study
ratn: not reported in source
RF-microchannel skin delivery
Comparator
Subcutaneous injection
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · transdermalAs given in this study (rat).
Source sentences
Summary
Creation of MCs in the outer layers of the skin enabled efficient delivery of hGH, with a bioavailability of 75% (rats) or 33% (GPs) relative to subcutaneous (s.c.) injection with plasma profiles resembling that of s.c. injection.
2 context sentences(design, population, supporting numbers)
Summary · context
Various doses of hGH in a dry form were applied on rat or guinea pig (GP) skin after the formation of MCs.
Summary · context
The pharmacokinetic profile of systemic hGH in both animal models was monitored for 15 h post patch application.
Report a problemFND-1584646203
04AnimalAnimal study (in vivo)Pharmacokinetics
In guinea pigs, transdermal hGH produced plasma profiles resembling those of subcutaneous injection.
In plain wordsIn guinea pigs, hGH through skin microchannels produced blood profiles resembling injection under the skin.
Peptide
HGH (somatotropin)
Outcome
Not applicablePlasma hGH profiles in guinea pigs
Study
guinea pign: not reported in source
RF-microchannel skin delivery
Comparator
Subcutaneous injection
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
Dose not stated · transdermalAs given in this study (guinea pig).
Source sentences
Summary
Creation of MCs in the outer layers of the skin enabled efficient delivery of hGH, with a bioavailability of 75% (rats) or 33% (GPs) relative to subcutaneous (s.c.) injection with plasma profiles resembling that of s.c. injection.
2 context sentences(design, population, supporting numbers)
Summary · context
Various doses of hGH in a dry form were applied on rat or guinea pig (GP) skin after the formation of MCs.
Summary · context
The pharmacokinetic profile of systemic hGH in both animal models was monitored for 15 h post patch application.
Report a problemFND-1584646204
05AnimalAnimal study (in vivo)Activity measurement
In hypophysectomized rats, systemic IGF-I increased after transdermal hGH delivery.
In plain wordsIn rats without a pituitary gland, blood IGF-I increased after hGH delivery through the skin.
Peptide
HGH (somatotropin)
Outcome
IncreaseSystemic IGF-I after transdermal hGH
Study
ratn: not reported in source
Hypophysectomized rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · transdermalAs given in this study (rat).
Source sentences
Summary
Elevated levels of systemic insulin-like growth factor-1 (IGF-I) were observed after transdermal delivery of hGH to hypophysectomized rats indicative of the bioactivity of the transdermally delivered hGH in vivo.
2 context sentences(design, population, supporting numbers)
Summary · context
Various doses of hGH in a dry form were applied on rat or guinea pig (GP) skin after the formation of MCs.
Summary · context
The pharmacokinetic profile of systemic hGH in both animal models was monitored for 15 h post patch application.
Report a problemFND-1584646205

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

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