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Study · Ex vivo tissue · 2006

3 results

A peptide preparation protects cells in organotypic brain slices against cell death after glutamate intoxication.

Riley C, Hutter-Paier B, Windisch M, Doppler E, Moessler H, Wronski R

Journal of neural transmission (Vienna, Austria : 1996)22 Apr 2005Cited by 28 (Europe PMC)

PMID15843866 (opens in a new tab)DOI10.1007/s00702-005-0302-8 (opens in a new tab)PepBankPUB-15843866
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In organotypic brain slices, Cerebrolysin showed its strongest protection against glutamate lesions when added before and after lesioning.

    In plain wordsIn lab tests, Cerebrolysin showed the strongest protection when added before and after glutamate injury.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCell death with pre- and post-lesion treatment
    Study

    n: not reported in source

    Organotypic brain slices
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The most pronounced effect was seen with the drug added both prior to and after the glutamate lesioning.
    2 context sentences
    Summary · context
    In the present study organotypic brain slices were utilized to determine the neuroprotective effects of Cerebrolysin, in a glutamate lesion paradigm mimicking a key event in ischemia.
    Summary · context
    Cerebrolysin was added either before and after the lesion or after the lesion only.
  2. 02LabEx vivo tissueEfficacy outcome

    In organotypic brain slices, Cerebrolysin added after glutamate lesioning counteracted necrosis.

    In plain wordsIn lab tests, Cerebrolysin added after glutamate injury reduced necrosis.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseNecrosis after post-lesion treatment
    Study

    n: not reported in source

    Organotypic brain slices
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A treatment after the lesion only also counteracted necrosis and apoptosis.
    2 context sentences
    Summary · context
    In the present study organotypic brain slices were utilized to determine the neuroprotective effects of Cerebrolysin, in a glutamate lesion paradigm mimicking a key event in ischemia.
    Summary · context
    Cerebrolysin was added either before and after the lesion or after the lesion only.
  3. 03LabEx vivo tissueEfficacy outcome

    In organotypic brain slices, Cerebrolysin added after glutamate lesioning counteracted apoptosis.

    In plain wordsIn lab tests, Cerebrolysin added after glutamate injury reduced apoptosis.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseApoptosis after post-lesion treatment
    Study

    n: not reported in source

    Organotypic brain slices
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A treatment after the lesion only also counteracted necrosis and apoptosis.
    2 context sentences
    Summary · context
    In the present study organotypic brain slices were utilized to determine the neuroprotective effects of Cerebrolysin, in a glutamate lesion paradigm mimicking a key event in ischemia.
    Summary · context
    Cerebrolysin was added either before and after the lesion or after the lesion only.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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