In Huntington disease transgenic mice, hypothalamic oxytocin mRNA expression was down-regulated, along with other hypothalamic neuropeptide mRNAs.
In plain wordsIn Huntington disease model mice, the body's own oxytocin gene activity in the hypothalamus was lower.
- Peptide
- Oxytocin
- Outcome
- DecreaseHypothalamic oxytocin mRNA expression
- Study
mousen: not reported in source
Huntington disease transgenic mice with expanded polyQ-EGFP- Outcome group
- Endogenous peptide levels · Nervous system and cognition
Source sentences
We show here that polyQ-EGFP aggregates were intense in the hypothalamus, where the expression of six hypothalamic neuropeptide mRNAs, such as oxytocin, vasopressin and cocaine-amphetamine-regulated transcript, was down-regulated in the transgenic mouse brain without observing a significant loss of…
1 context sentence(design, population, supporting numbers)
We generated transgenic mouse lines expressing mutant truncated N-terminal huntingtin (expanded polyQ) fused with enhanced green fluorescent protein (EGFP) and carried out a high-density oligonucleotide array analysis using mRNA extracted from the cerebrum, followed by TaqMan RT-PCR and in situ hybridization.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.