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Study · Animal study (in vivo) · rat · 2005

6 results

[Effect of new synthetic anxiolytic selank on gastric wall blood flow and mesenteryc lymphatic vessels contractility in anesthetized rats].

Pavlov TS, Sanzhieva LTs, Samonina GE, Sergeev VI, Lelekova TV

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Feb 2005

PMID15835541 (opens in a new tab)PepBankPUB-15835541
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, Selank did not change basal gastric blood flow.

    In plain wordsIn rats, Selank did not change normal blood flow in the stomach wall.

    Peptide
    Selank
    Outcome
    No significant changeBasal gastric blood flow
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank fail to influence basal gastric blood flow but it can normalize blood flow reduced by indomethacin.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, Selank normalized gastric blood flow that indomethacin had reduced.

    In plain wordsIn rats, Selank brought stomach blood flow back to normal after indomethacin had lowered it.

    Peptide
    Selank
    Outcome
    IncreaseGastric blood flow reduced by indomethacin
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Selank fail to influence basal gastric blood flow but it can normalize blood flow reduced by indomethacin.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    At low concentrations, Selank enhanced the amplitude of mesenteric lymphatic vessel contractions in rats.

    In plain wordsIn rats, low concentrations of Selank increased the strength of contractions in lymph vessels.

    Peptide
    Selank
    Outcome
    IncreaseLymphatic vessel contraction amplitude, low concentration
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10(-12)--10(-14) MAs given in this study (rat).

    Source sentences

    Summary
    The study of dose-depended of Selank effect on lymphatic vessels contractility showed that its low concentration (10(-12)--10(-14) M) enhanced amplitude and increase frequency of lymphatic vessel contractions which indicates an enhancement of lymphatic flow.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    At low concentrations, Selank increased the frequency of mesenteric lymphatic vessel contractions in rats.

    In plain wordsIn rats, low concentrations of Selank made lymph vessels contract more often.

    Peptide
    Selank
    Outcome
    IncreaseLymphatic vessel contraction frequency, low concentration
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10(-12)--10(-14) MAs given in this study (rat).

    Source sentences

    Summary
    The study of dose-depended of Selank effect on lymphatic vessels contractility showed that its low concentration (10(-12)--10(-14) M) enhanced amplitude and increase frequency of lymphatic vessel contractions which indicates an enhancement of lymphatic flow.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    At high doses, Selank also augmented the amplitude of mesenteric lymphatic vessel contractions in rats.

    In plain wordsIn rats, higher concentrations of Selank also increased the strength of lymph vessel contractions.

    Peptide
    Selank
    Outcome
    IncreaseLymphatic vessel contraction amplitude, high concentration
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10(-6)--10(-10) MAs given in this study (rat).

    Source sentences

    Summary
    The high doses of peptide (10(-6)--10(-10) M) also augmented the contraction amplitude but decreased its frequency.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    At high doses, Selank decreased the frequency of mesenteric lymphatic vessel contractions in rats.

    In plain wordsIn rats, higher concentrations of Selank made lymph vessels contract less often.

    Peptide
    Selank
    Outcome
    DecreaseLymphatic vessel contraction frequency, high concentration
    Study

    ratn: not reported in source

    anesthetized white rats
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10(-6)--10(-10) MAs given in this study (rat).

    Source sentences

    Summary
    The high doses of peptide (10(-6)--10(-10) M) also augmented the contraction amplitude but decreased its frequency.
    1 context sentence
    Summary · context
    Action of the peptide on gastric blood flow in the stomach by using the method ofhydrogenic clearance and Selank action on mesenteric lymphatic contractility by microscopical observation in situ, were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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