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Study · Not a test of the peptide alone · 2005

5 results

The GHRH/GHRP-6 test for the diagnosis of GH deficiency in elderly or severely obese men.

Haijma SV, van Dam PS, de Vries WR, Maitimu-Smeele I, Dieguez C, Casanueva FF, Koppeschaar HP

European journal of endocrinology1 Apr 2005Cited by 12 (Europe PMC)

PMID15817913 (opens in a new tab)DOI10.1530/eje.1.01887 (opens in a new tab)PepBankPUB-15817913
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In severely obese men, peak GH after combined GHRH/GHRP‑6 was significantly lower than in controls.

    In plain wordsSeverely obese men had a lower GH peak than controls after combined GHRH and GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreasePeak GH in obese men
    Study

    n: not reported in source

    Combined GHRH/GHRP-6 diagnostic test
    Comparator
    Healthy male controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    13.2 microg/l
    Obese men
    Peak GH
    53.4 microg/l
    Controls

    Source sentences

    Summary
    Both peak GH levels and areas under the curve (AUC) were significantly lower in the obese than in the controls (peak 13.2 vs 53.4 microg/l, P = 0.001; AUC 707 vs 3250 microg/l x 120 min; P = 0.001).
    2 context sentences
    Summary · context
    We performed a combined GHRH/GHRP-6 test in ten elderly men (mean age 74 years; mean body mass index (BMI) 24.6 kg/m(2)), nine obese men (mean age 47 years; mean BMI 40.6 kg/m(2)) and seven healthy male controls (mean age 51 years, mean BMI 24.3 kg/m(2)).
    Summary · context
    After assessment of fasting plasma GH, IGF-I and IGF-binding protein-3 (IGFBP-3), GHRH (100 microg) and GHRP-6 (93 microg) were given intravenously as a bolus injection.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In severely obese men, GH AUC after combined GHRH/GHRP‑6 was significantly lower than in controls.

    In plain wordsSeverely obese men had a lower total GH response than controls after combined GHRH and GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH AUC in obese men
    Study

    n: not reported in source

    Combined GHRH/GHRP-6 diagnostic test
    Comparator
    Healthy male controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    707 microg/l x 120 min
    Obese men
    GH AUC
    3250 microg/l x 120 min
    Controls

    Source sentences

    Summary
    Both peak GH levels and areas under the curve (AUC) were significantly lower in the obese than in the controls (peak 13.2 vs 53.4 microg/l, P = 0.001; AUC 707 vs 3250 microg/l x 120 min; P = 0.001).
    2 context sentences
    Summary · context
    We performed a combined GHRH/GHRP-6 test in ten elderly men (mean age 74 years; mean body mass index (BMI) 24.6 kg/m(2)), nine obese men (mean age 47 years; mean BMI 40.6 kg/m(2)) and seven healthy male controls (mean age 51 years, mean BMI 24.3 kg/m(2)).
    Summary · context
    After assessment of fasting plasma GH, IGF-I and IGF-binding protein-3 (IGFBP-3), GHRH (100 microg) and GHRP-6 (93 microg) were given intravenously as a bolus injection.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In elderly men, peak GH after combined GHRH/GHRP‑6 was lower than in controls, without statistical significance.

    In plain wordsElderly men had no significant difference in peak GH compared with controls after combined GHRH and GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak GH in elderly men
    Study

    n: not reported in source

    Combined GHRH/GHRP-6 diagnostic test
    Comparator
    Healthy male controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    35 microg/l
    Elderly men

    Source sentences

    Summary
    Mean GH response in the elderly was lower than in the controls (peak 35.0 microg/l; AUC 2274 microg/l x 120 min), but this was not statistically significant.
    2 context sentences
    Summary · context
    We performed a combined GHRH/GHRP-6 test in ten elderly men (mean age 74 years; mean body mass index (BMI) 24.6 kg/m(2)), nine obese men (mean age 47 years; mean BMI 40.6 kg/m(2)) and seven healthy male controls (mean age 51 years, mean BMI 24.3 kg/m(2)).
    Summary · context
    After assessment of fasting plasma GH, IGF-I and IGF-binding protein-3 (IGFBP-3), GHRH (100 microg) and GHRP-6 (93 microg) were given intravenously as a bolus injection.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    In elderly men, GH AUC after combined GHRH/GHRP‑6 was lower than in controls, without statistical significance.

    In plain wordsElderly men had no significant difference in total GH response compared with controls after combined GHRH and GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH AUC in elderly men
    Study

    n: not reported in source

    Combined GHRH/GHRP-6 diagnostic test
    Comparator
    Healthy male controls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    2274 microg/l x 120 min
    Elderly men

    Source sentences

    Summary
    Mean GH response in the elderly was lower than in the controls (peak 35.0 microg/l; AUC 2274 microg/l x 120 min), but this was not statistically significant.
    2 context sentences
    Summary · context
    We performed a combined GHRH/GHRP-6 test in ten elderly men (mean age 74 years; mean body mass index (BMI) 24.6 kg/m(2)), nine obese men (mean age 47 years; mean BMI 40.6 kg/m(2)) and seven healthy male controls (mean age 51 years, mean BMI 24.3 kg/m(2)).
    Summary · context
    After assessment of fasting plasma GH, IGF-I and IGF-binding protein-3 (IGFBP-3), GHRH (100 microg) and GHRP-6 (93 microg) were given intravenously as a bolus injection.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  5. 05HumanNot a test of GHRP-6 aloneNon-randomized trialActivity measurement

    After combined GHRH/GHRP‑6, seven obese men had GH peaks below the 15.0 microg/l cut-off for severe GH deficiency; all others had peaks above it.

    In plain wordsAfter combined GHRH and GHRP‑6, seven obese men had GH peaks below the severe GH deficiency threshold. All others were above it.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH peak relative to severe GH deficiency cut-off
    Study

    n: not reported in source

    Combined GHRH/GHRP-6 diagnostic test
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Obese men with GH peak below cut-off
    7 men
    GH peak below the 15.0 microg/l cut-off

    Source sentences

    Summary
    In contrast, GH peak levels in seven obese men remained below the cut-off level of 15.0 microg/l associated with severe GH deficiency.
    Summary
    All others had GH peak levels exceeding this threshold.
    1 context sentence
    Summary · context
    We performed a combined GHRH/GHRP-6 test in ten elderly men (mean age 74 years; mean body mass index (BMI) 24.6 kg/m(2)), nine obese men (mean age 47 years; mean BMI 40.6 kg/m(2)) and seven healthy male controls (mean age 51 years, mean BMI 24.3 kg/m(2)).

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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