Intermittently administered parathyroid hormone 1-34 reverses bone loss and structural impairment in orchiectomized adult rats.

Gabet Y, Kohavi D, Müller R, Chorev M, Bab I

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA6 Apr 2005Cited by 26 (Europe PMC)

PMID15812598DOI10.1007/s00198-005-1876-6PepBankPUB-15812598

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH induced 155% recovery of trabecular bone loss.
In plain wordsIn orchiectomized rats, PTH restored lost trabecular bone volume beyond the original level compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular bone volume density recovery
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Measurements
Bone loss recovery
155%
PTH
Source sentences
Summary
PTH(1-34) induced supraphysiologic recovery of this bone loss (155% recovery) consequent to a vast increase in trabecular thickness (174% over sham-ORX controls) and a partial reversal (62%) of the decrease in trabecular number.
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259801
02AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH increased trabecular thickness by 174% over sham-orchiectomized controls.
In plain wordsIn orchiectomized rats, PTH increased trabecular thickness versus sham-operated controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular thickness
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Sham-orchiectomized controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Measurements
Trabecular thickness increase
174%
over sham-ORX controls
Source sentences
Summary
PTH(1-34) induced supraphysiologic recovery of this bone loss (155% recovery) consequent to a vast increase in trabecular thickness (174% over sham-ORX controls) and a partial reversal (62%) of the decrease in trabecular number.
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259802
03AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH reversed 62% of the decrease in trabecular number.
In plain wordsIn orchiectomized rats, PTH partly restored trabecular number compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseTrabecular number recovery
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Measurements
Reversal of trabecular number decrease
62%
PTH
Source sentences
Summary
PTH(1-34) induced supraphysiologic recovery of this bone loss (155% recovery) consequent to a vast increase in trabecular thickness (174% over sham-ORX controls) and a partial reversal (62%) of the decrease in trabecular number.
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259803
04AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH decreased osteoclast number by 20% versus vehicle.
In plain wordsIn orchiectomized rats, PTH decreased osteoclast number versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseOsteoclast number
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Measurements
Osteoclast number reduction
20%
versus vehicle
Source sentences
Summary
As compared with the results in 12-week, orchiectomized vehicle-administered rats, the PTH(1-34) treatment induced a significant decrease in osteoclast number (20%) and twofold increase in bone formation rate.
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259804
05AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH doubled bone formation rate versus vehicle.
In plain wordsIn orchiectomized rats, PTH doubled bone formation rate versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone formation rate
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Source sentences
Summary
As compared with the results in 12-week, orchiectomized vehicle-administered rats, the PTH(1-34) treatment induced a significant decrease in osteoclast number (20%) and twofold increase in bone formation rate.
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259805
06AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH induced marked cortical thickening in the femoral diaphysis.
In plain wordsIn orchiectomized rats, PTH increased cortical bone thickness compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCortical thickness
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Source sentences
Summary
While ORX did not affect the femoral diaphysis, PTH(1-34) induced marked cortical thickening via the stimulation of endosteal mineral appositional rate (154% over ORX rats).
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259806
07AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, PTH increased endosteal mineral appositional rate by 154% over untreated orchiectomized rats.
In plain wordsIn orchiectomized rats, PTH increased endosteal mineral deposition versus untreated orchiectomized rats.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseEndosteal mineral appositional rate
Study
ratn: not reported in source
Orchiectomized adult rats
Comparator
Orchiectomized vehicle-treated rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg/day · 6 weeksAs given in this study (rat).
Measurements
Endosteal mineral appositional rate increase
154%
over ORX rats
Source sentences
Summary
While ORX did not affect the femoral diaphysis, PTH(1-34) induced marked cortical thickening via the stimulation of endosteal mineral appositional rate (154% over ORX rats).
2 context sentences(design, population, supporting numbers)
Summary · context
Bilateral orchiectomy (ORX) or sham-ORX was performed in 13-week old rats.
Summary · context
Five weeks later, the ORX rats were treated intermittently with human PTH(1-34), 80 microg/kg/day or vehicle for 6 weeks.
Report a problemFND-1581259807

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Version history

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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