Joint mechanisms of impaired growth-hormone pulse renewal in aging men.

Veldhuis JD, Iranmanesh A, Bowers CY

The Journal of clinical endocrinology and metabolism5 Apr 2005Cited by 15 (Europe PMC)

PMID15811926DOI10.1210/jc.2005-0336PepBankPUB-15811926

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

01HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In healthy men, percentage GH feedback inhibition correlated negatively with total IGF-I concentrations after an rhGH pulse followed by a GHRP‑2 bolus.
In plain wordsIn healthy men, higher IGF-I went with less growth hormone feedback inhibition after a GH pulse and a GHRP‑2 bolus.
Peptide
GHRP-2
Outcome
DecreaseGH feedback inhibition versus total IGF-I after rhGH then GHRP-2
Study
n = 17
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
R2
0.4
IGF-I after rhGH/GHRP-2
Source sentences
Summary
2) total IGF-I concentrations after rh GH/GHRP-2 infusion (R(2) = 0.40, P = 0.009)
2 context sentences(design, population, supporting numbers)
Summary · context
In a university setting, 17 healthy men ages 19-71 yr each underwent four randomly ordered infusion studies on separate mornings fasting.
Summary · context
Intravenous injection of a pulse of: 1) saline or 2) recombinant human (rh) GH to impose controlled negative feedback, followed in 2 h by a bolus of 3) saline or (iv) the ghrelin analog GHRP-2 to overcome feedback inhibition.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1581192601
02HumanNot a test of GHRP-2 aloneRandomized controlled trialMechanism
In healthy men, sex-steroid concentrations and body mass index were unrelated to the degree of GH autoinhibition.
In plain wordsIn healthy men, sex hormones and body mass index were not linked to how strongly growth hormone inhibited itself.
Peptide
GHRP-2
Outcome
No significant changeGH autoinhibition versus sex steroids and BMI
Study
n = 17
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In contrast, sex-steroid concentrations and body mass index were unrelated to degree of autoinhibition.
2 context sentences(design, population, supporting numbers)
Summary · context
In a university setting, 17 healthy men ages 19-71 yr each underwent four randomly ordered infusion studies on separate mornings fasting.
Summary · context
Intravenous injection of a pulse of: 1) saline or 2) recombinant human (rh) GH to impose controlled negative feedback, followed in 2 h by a bolus of 3) saline or (iv) the ghrelin analog GHRP-2 to overcome feedback inhibition.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1581192602

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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