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Study · Measured the body's own peptide · 2005

4 results

Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement.

Light KC, Grewen KM, Amico JA, Brownley KA, West SG, Hinderliter AL, Girdler SS

Hormones and behavior1 May 2005Cited by 33 (Europe PMC)

PMID15811355 (opens in a new tab)DOI10.1016/j.yhbeh.2004.12.010 (opens in a new tab)PepBankPUB-15811355
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In postmenopausal women, oral conjugated estrogens alone and with progesterone, but not placebo, increased plasma oxytocin intermediate peptide levels.

    In plain wordsIn postmenopausal women, estrogen therapy raised the body's own oxytocin intermediate peptide levels, while placebo did not.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin intermediate peptide
    Study

    n = 54

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    ERT alone and with progesterone (but not placebo) led to significant increases in plasma levels of OT Int, but no change in plasma OT levels.
    1 context sentence
    Summary · context
    Thus, we used plasma obtained at rest and during a speech stressor from 54 postmenopausal women who participated in a 6-month randomized trial of oral conjugated estrogens vs. placebo to examine effects of estrogen replacement therapy (ERT) on plasma OT and OT Int levels and their relationships to c…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In postmenopausal women, estrogen replacement therapy did not change plasma oxytocin levels.

    In plain wordsIn postmenopausal women, estrogen therapy did not change the body's own oxytocin levels in blood.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin level
    Study

    n = 54

    Comparator
    Placebo
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    ERT alone and with progesterone (but not placebo) led to significant increases in plasma levels of OT Int, but no change in plasma OT levels.
    1 context sentence
    Summary · context
    Thus, we used plasma obtained at rest and during a speech stressor from 54 postmenopausal women who participated in a 6-month randomized trial of oral conjugated estrogens vs. placebo to examine effects of estrogen replacement therapy (ERT) on plasma OT and OT Int levels and their relationships to c…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In postmenopausal women in a 6-month trial of oral conjugated estrogens versus placebo, greater increases in oxytocin intermediate peptide during treatment were linked to greater decreases in blood pressure during behavioral stressors, after controlling for treatment condition.

    In plain wordsIn postmenopausal women in an estrogen trial, bigger rises in the body's own oxytocin intermediate peptide were linked to bigger blood pressure drops during stress.

    Peptide
    Oxytocin
    Outcome
    DecreaseBlood pressure change in relation to oxytocin intermediate peptide increase
    Study

    n = 54

    Comparator
    Women with moderate or no increases in OT Int
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Women showing greater increases in OT Int during treatment showed greater decreases in BP and total vascular resistance during a series of behavioral stressors compared to women with moderate or no increases in OT Int, even after controlling for effects related to treatment condition or to changes in plasma estradiol.
    1 context sentence
    Summary · context
    Thus, we used plasma obtained at rest and during a speech stressor from 54 postmenopausal women who participated in a 6-month randomized trial of oral conjugated estrogens vs. placebo to examine effects of estrogen replacement therapy (ERT) on plasma OT and OT Int levels and their relationships to c…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In postmenopausal women in a 6-month trial of oral conjugated estrogens versus placebo, greater increases in oxytocin intermediate peptide during treatment were linked to greater decreases in total vascular resistance during behavioral stressors, after controlling for treatment condition.

    In plain wordsIn postmenopausal women in an estrogen trial, bigger rises in the body's own oxytocin intermediate peptide were linked to bigger vascular resistance drops in stress.

    Peptide
    Oxytocin
    Outcome
    DecreaseTotal vascular resistance change in relation to oxytocin intermediate peptide increase
    Study

    n = 54

    Comparator
    Women with moderate or no increases in OT Int
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Women showing greater increases in OT Int during treatment showed greater decreases in BP and total vascular resistance during a series of behavioral stressors compared to women with moderate or no increases in OT Int, even after controlling for effects related to treatment condition or to changes in plasma estradiol.
    1 context sentence
    Summary · context
    Thus, we used plasma obtained at rest and during a speech stressor from 54 postmenopausal women who participated in a 6-month randomized trial of oral conjugated estrogens vs. placebo to examine effects of estrogen replacement therapy (ERT) on plasma OT and OT Int levels and their relationships to c…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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