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Study · Animal study (in vivo) · rat · 2005

4 results

Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin.

Lee PR, Brady DL, Shapiro RA, Dorsa DM, Koenig JI

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology1 Oct 2005Cited by 152 (Europe PMC)

PMID15798779 (opens in a new tab)DOI10.1038/sj.npp.1300722 (opens in a new tab)PepBankPUB-15798779
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats with chronic phencyclidine-induced social deficits, bilateral oxytocin infusion into the central amygdala restored the normal quantity and quality of social behavior.

    In plain wordsIn rats with phencyclidine-induced social deficits, oxytocin infused into a brain area called the central amygdala restored normal social behavior.

    Peptide
    Oxytocin
    Outcome
    IncreaseSocial behavior restoration after central amygdala oxytocin
    Study

    ratn: not reported in source

    Chronic PCP rat model of schizophrenia social deficit
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    1 mug · bilateral infusion into the central amygdalaAs given in this study (rat).

    Source sentences

    Summary
    A bilateral infusion of 1 mug of oxytocin into the central amygdala selectively restored the normal quantity and quality of social behavior in chronic PCP-treated male rats without altering open field behaviors.
    1 context sentence
    Summary · context
    Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats with chronic phencyclidine treatment, central amygdala oxytocin infusion did not alter open field behaviors.

    In plain wordsIn rats given phencyclidine, oxytocin infused into the central amygdala did not change open field behavior.

    Peptide
    Oxytocin
    Outcome
    No significant changeOpen field behavior after central amygdala oxytocin
    Study

    ratn: not reported in source

    Chronic PCP rat model of schizophrenia social deficit
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    1 mug · bilateral infusion into the central amygdalaAs given in this study (rat).

    Source sentences

    Summary
    A bilateral infusion of 1 mug of oxytocin into the central amygdala selectively restored the normal quantity and quality of social behavior in chronic PCP-treated male rats without altering open field behaviors.
    1 context sentence
    Summary · context
    Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats treated chronically with phencyclidine, hypothalamic oxytocin mRNA expression was significantly lower than in controls.

    In plain wordsIn rats given phencyclidine for a long time, the body's own oxytocin gene activity in the hypothalamus was lower.

    Peptide
    Oxytocin
    Outcome
    DecreaseHypothalamic oxytocin mRNA expression
    Study

    ratn: not reported in source

    Chronic PCP rat model of schizophrenia social deficit
    Comparator
    Saline-treated control
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Hypothalamic oxytocin mRNA expression was significantly decreased while oxytocin receptor binding was increased in the central nucleus of the amygdala following chronic PCP treatment.
    1 context sentence
    Summary · context
    Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats treated chronically with phencyclidine, oxytocin receptor binding in the central nucleus of the amygdala was increased.

    In plain wordsIn rats given phencyclidine for a long time, binding of the body's own oxytocin to its receptor rose in the central amygdala.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin receptor binding in central amygdala
    Study

    ratn: not reported in source

    Chronic PCP rat model of schizophrenia social deficit
    Comparator
    Saline-treated control
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Hypothalamic oxytocin mRNA expression was significantly decreased while oxytocin receptor binding was increased in the central nucleus of the amygdala following chronic PCP treatment.
    1 context sentence
    Summary · context
    Chronic administration of phencyclidine (PCP) has been advanced as a valid animal model of the social deficit symptoms of schizophrenia.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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