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Study · Animal study (in vivo) · rat · 2005

3 results

Long-term AICAR administration and exercise prevents diabetes in ZDF rats.

Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S

Diabetes1 Apr 2005Cited by 168 (Europe PMC)

PMID15793229 (opens in a new tab)DOI10.2337/diabetes.54.4.928 (opens in a new tab)PepBankPUB-15793229
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prediabetic ZDF rats, AICAR prevented hyperglycemia during the intervention, unlike untreated rats.

    In plain wordsIn prediabetic rats, AICAR prevented high blood glucose compared with untreated rats.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseDevelopment of hyperglycemia
    Study

    ratn: not reported in source

    male Zucker diabetic fatty rats
    Comparator
    untreated ZDF rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    In contrast to the untreated, both the exercised and AICAR-treated rats did not develop hyperglycemia during the intervention period.
    1 context sentence
    Summary · context
    Five-week-old, pre-diabetic ZDF rats underwent daily treadmill running or AICAR treatment over an 8-week period and were compared with an untreated group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ZDF rats, AICAR markedly increased whole-body insulin sensitivity versus untreated rats.

    In plain wordsIn rats, AICAR increased insulin sensitivity compared with untreated rats.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseWhole-body insulin sensitivity
    Study

    ratn: not reported in source

    male Zucker diabetic fatty rats
    Comparator
    untreated ZDF rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    Whole-body insulin sensitivity, as assessed by a hyperinsulinemic-euglycemic clamp at the end of the intervention period, was markedly increased in the exercised and AICAR-treated animals compared with the untreated ZDF rats (P < 0.01).
    1 context sentence
    Summary · context
    Five-week-old, pre-diabetic ZDF rats underwent daily treadmill running or AICAR treatment over an 8-week period and were compared with an untreated group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In AICAR-treated ZDF rats, pancreatic beta-cell morphology was almost normal.

    In plain wordsIn rats treated with AICAR, pancreatic insulin-producing cells had an almost normal appearance.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicablePancreatic beta-cell morphology
    Study

    ratn: not reported in source

    male Zucker diabetic fatty rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · 8 weeksAs given in this study (rat).

    Source sentences

    Summary
    In addition, pancreatic beta-cell morphology was almost normal in the exercised and AICAR-treated animals, indicating that chronic AMPK activation in vivo might preserve beta-cell function.
    1 context sentence
    Summary · context
    Five-week-old, pre-diabetic ZDF rats underwent daily treadmill running or AICAR treatment over an 8-week period and were compared with an untreated group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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