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Study · Animal study (in vivo) · rat · 2005

3 results

Feeding responses to a melanocortin agonist and antagonist in obesity induced by a palatable high-fat diet.

Hansen MJ, Schiöth HB, Morris MJ

Brain research1 Mar 2005Cited by 28 (Europe PMC)

PMID15781055 (opens in a new tab)DOI10.1016/j.brainres.2005.01.063 (opens in a new tab)PepBankPUB-15781055
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular melanotan II had a long-lasting inhibitory effect on food intake.

    In plain wordsIn rats, melanotan II given into the brain reduced food intake for a long time.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after MTII
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats on high-fat cafeteria diet or chow
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    MTII had a long-lasting inhibitory effect on food intake.
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats fed a high-fat cafeteria diet (30% fat) or chow (5% fat) for 4 or 12 weeks were implanted with intracerebroventricular cannulae and feeding responses to the MC3/4R agonist MTII (0.5 nmol) and the selective MC4R antagonist HS014 (0.8 nmol) were determined.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats fed a high-fat diet, the inhibitory effect of melanotan II on food intake 15 and 24 h after injection was significantly greater than in control rats.

    In plain wordsIn rats fed a high-fat diet, melanotan II cut food intake more than in chow-fed control rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseInhibitory feeding response 15 and 24 h after MTII in chronically overfed rats
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats on high-fat cafeteria diet or chow
    Comparator
    Chow-fed control rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.5 nmol · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Chronically overfed animals had a significantly exaggerated inhibitory feeding response 15 and 24 h after MTII injection
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats fed a high-fat cafeteria diet (30% fat) or chow (5% fat) for 4 or 12 weeks were implanted with intracerebroventricular cannulae and feeding responses to the MC3/4R agonist MTII (0.5 nmol) and the selective MC4R antagonist HS014 (0.8 nmol) were determined.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats fed a high-fat diet, melanotan II caused significantly more body weight loss than in control rats.

    In plain wordsIn rats fed a high-fat diet, melanotan II caused more weight loss than in chow-fed control rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight loss after MTII
    Study

    ratn: not reported in source

    Male Sprague-Dawley rats on high-fat cafeteria diet or chow
    Comparator
    Chow-fed control rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.5 nmol · intracerebroventricularAs given in this study (rat).

    Measurements

    Body weight loss
    15 g
    chronically overfed rats
    Body weight loss
    4 g
    control rats

    Source sentences

    Summary
    and lost more body weight (15 +/- 3 g) compared to control rats (4 +/- 4 g; P < 0.05).
    1 context sentence
    Summary · context
    Male Sprague-Dawley rats fed a high-fat cafeteria diet (30% fat) or chow (5% fat) for 4 or 12 weeks were implanted with intracerebroventricular cannulae and feeding responses to the MC3/4R agonist MTII (0.5 nmol) and the selective MC4R antagonist HS014 (0.8 nmol) were determined.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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