Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora.

Komatsubara S, Mori S, Mashiba T, Nonaka K, Seki A, Akiyama T, Miyamoto K, Cao Y, Manabe T, Norimatsu H

Bone1 Apr 2005Cited by 112 (Europe PMC)

PMID15781006DOI10.1016/j.bone.2005.02.002PepBankPUB-15781006

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with femoral osteotomy, total cross-sectional area did not differ significantly among treatment groups at any time point.
In plain wordsIn rats with femoral osteotomy, total cross-sectional area did not differ significantly among groups, including vehicle controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeTotal cross-sectional area
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
All groups including vehicle control
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · subcutaneousAs given in this study (rat).
Source sentences
Summary
Total cross-sectional area was not significantly different among all groups at any time point.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, continued PTH at 10 microg/kg increased lamellar bone/callus area at 3 weeks versus other groups.
In plain wordsIn rats, continued PTH at 10 microg/kg increased lamellar bone/callus area versus other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLamellar bone/callus area at 3 weeks
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
Other groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg three times weekly before and after surgery · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 3 weeks after surgery, the lamellar bone/callus area was significantly increased in C10 and C30 groups compared to the other groups.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, continued PTH at 30 microg/kg increased lamellar bone/callus area at 3 weeks versus other groups.
In plain wordsIn rats, continued PTH at 30 microg/kg increased lamellar bone/callus area versus other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLamellar bone/callus area at 3 weeks
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
Other groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 microg/kg three times weekly before and after surgery · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 3 weeks after surgery, the lamellar bone/callus area was significantly increased in C10 and C30 groups compared to the other groups.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, continued PTH at 10 microg/kg increased percent new cortical shell area at 12 weeks versus other groups.
In plain wordsIn rats, continued PTH at 10 microg/kg increased new cortical shell area versus other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseNew cortical shell area at 12 weeks
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
Other groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
10 microg/kg three times weekly before and after surgery · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 12 weeks, percent new cortical shell area was significantly higher in C10 and C30 groups compared to the other groups, and the ultimate load in mechanical testing was significantly higher in C30 group than in CNT, P10, and P30 groups.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100604
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, continued PTH at 30 microg/kg increased percent new cortical shell area at 12 weeks versus other groups.
In plain wordsIn rats, continued PTH at 30 microg/kg increased new cortical shell area versus other groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseNew cortical shell area at 12 weeks
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
Other groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 microg/kg three times weekly before and after surgery · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 12 weeks, percent new cortical shell area was significantly higher in C10 and C30 groups compared to the other groups, and the ultimate load in mechanical testing was significantly higher in C30 group than in CNT, P10, and P30 groups.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100605
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, continued PTH at 30 microg/kg increased ultimate load versus vehicle and pretreatment-only groups at 12 weeks.
In plain wordsIn rats, continued PTH at 30 microg/kg increased ultimate load versus vehicle and pretreatment-only groups.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseUltimate load at 12 weeks
Study
ratn: not reported in source
Surgical femoral osteotomy
Comparator
Vehicle control and pretreatment-only P10 and P30 groups
Outcome group
Bone and joint · Musculoskeletal
Studied dose
30 microg/kg three times weekly before and after surgery · subcutaneousAs given in this study (rat).
Source sentences
Summary
At 12 weeks, percent new cortical shell area was significantly higher in C10 and C30 groups compared to the other groups, and the ultimate load in mechanical testing was significantly higher in C30 group than in CNT, P10, and P30 groups.
3 context sentences(design, population, supporting numbers)
Summary · context
One hundred five, 5-week-old SD rats were allocated to vehicle control (CNT) and four PTH groups; 10 and 30 microg/kg of hPTH(1-34) treatment before surgery (P10, P30), and treatment before and after surgery (C10, C30).
Summary · context
All animals were given subcutaneous injections three times a week for 3 weeks.
Summary · context
Human PTH(1-34) treatment was continued in C10 and C30 groups until sacrifice at 3, 6, and 12 weeks after surgery.
Report a problemFND-1578100606

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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