Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress.

Popovic V, Pekic S, Pavlovic D, Maric N, Jasovic-Gasic M, Djurovic B, Medic Stojanoska M, Zivkovic V, Stojanovic M, Doknic M, Milic N, Djurovic M, Dieguez C, Casanueva FF

Journal of endocrinological investigation1 Dec 2004Cited by 131 (Europe PMC)

PMID15754737DOI10.1007/bf03345308PepBankPUB-15754737

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors evaluated with GHRH plus GHRP‑6, severe GH deficiency occurred in 15%.
In plain wordsThe combined test identified severe GH deficiency in 15% of TBI survivors.
Peptide
GHRP-6
Outcome
Not applicableSevere GH deficiency
Study
n = 67
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Severe GH deficiency
15%
TBI patients
Source sentences
Summary
Severe GHD is the most frequent deficiency present in 15% of TBI patients.
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473701
02HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors, GH peaks after GHRH plus GHRP‑6 correlated positively with RAVLT total score, with p = 0.06.
In plain wordsIn TBI survivors, higher GH peaks after the combined test were linked to higher verbal learning scores, with p = 0.06.
Peptide
GHRP-6
Outcome
IncreaseGH peak and RAVLT total score
Study
n = 67
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Neuropsychological testing revealed a significant positive correlation of peak GH levels after GHRH+GHJRP-6 test with verbal learning and verbal short term memory (RAVLT total score p = 0.06, immediate free recall p = 0.02 and delayed free recall p = 0.04).
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473702
03HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors, GH peaks after GHRH plus GHRP‑6 correlated positively with immediate free recall.
In plain wordsIn TBI survivors, higher GH peaks after the combined test were linked to better immediate verbal recall.
Peptide
GHRP-6
Outcome
IncreaseGH peak and immediate free recall
Study
n = 67
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Neuropsychological testing revealed a significant positive correlation of peak GH levels after GHRH+GHJRP-6 test with verbal learning and verbal short term memory (RAVLT total score p = 0.06, immediate free recall p = 0.02 and delayed free recall p = 0.04).
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473703
04HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors, GH peaks after GHRH plus GHRP‑6 correlated positively with delayed free recall.
In plain wordsIn TBI survivors, higher GH peaks after the combined test were linked to better delayed verbal recall.
Peptide
GHRP-6
Outcome
IncreaseGH peak and delayed free recall
Study
n = 67
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Neuropsychological testing revealed a significant positive correlation of peak GH levels after GHRH+GHJRP-6 test with verbal learning and verbal short term memory (RAVLT total score p = 0.06, immediate free recall p = 0.02 and delayed free recall p = 0.04).
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473704
05HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors, paranoid ideation correlated negatively with GH peaks after GHRH plus GHRP‑6.
In plain wordsIn TBI survivors, higher GH peaks after the combined test were linked to less paranoid ideation.
Peptide
GHRP-6
Outcome
DecreaseGH peak and paranoid ideation
Study
n = 67
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Paranoid ideation and somatization negatively correlated with the peak GH responses to GHRH+GHRP-6 test (p = 0.04 and p = 0.03, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473705
06HumanNot a test of GHRP-6 aloneObservational studyOther
In TBI survivors, somatization correlated negatively with GH peaks after GHRH plus GHRP‑6.
In plain wordsIn TBI survivors, higher GH peaks after the combined test were linked to less somatization.
Peptide
GHRP-6
Outcome
DecreaseGH peak and somatization
Study
n = 67
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Paranoid ideation and somatization negatively correlated with the peak GH responses to GHRH+GHRP-6 test (p = 0.04 and p = 0.03, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
We present the results of endocrine, neurological, neuropsychological and psychiatric evaluation in a group of 67 patients who suffered TBI at least one yr ago.
Summary · context
GH/IGF-I axis was evaluated by GHRH+GHRP-6 test and IGF-I measurement.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-1575473706

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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