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Study · Not a test of the peptide alone · 2005

4 results

Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons.

Aton SJ, Colwell CS, Harmar AJ, Waschek J, Herzog ED

Nature neuroscience6 Mar 2005Cited by 619 (Europe PMC)

PMID15750589 (opens in a new tab)PMCIDPMC1628303 (opens in a new tab)DOI10.1038/nn1419 (opens in a new tab)PepBankPUB-15750589
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 01AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Mechanism

    In Vip-/- and Vipr2-/- mice, activity showed two daily bouts in a skeleton photoperiod and multiple circadian periods in constant darkness.

    In plain wordsIn mice lacking VIP or its receptor, daily activity patterns were disturbed, with two activity bouts a day and several rhythm periods in the dark.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableDaily activity pattern in VIP-deficient mice
    Study

    mousen: not reported in source

    Vip-/- and Vipr2-/- mice, suprachiasmatic nucleus neurons
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    We found that Vip(-/-) and Vipr2(-/-) mice showed two daily bouts of activity in a skeleton photoperiod and multiple circadian periods in constant darkness.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 02AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Mechanism

    In mice, loss of VIP or VPAC(2) abolished circadian firing rhythms in approximately half of all SCN neurons.

    In plain wordsIn mice, loss of VIP or its receptor stopped the daily firing rhythm in about half of the clock neurons.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseCircadian firing rhythms of SCN neurons
    Study

    mousen: not reported in source

    Vip-/- and Vipr2-/- mice, suprachiasmatic nucleus neurons
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    Loss of VIP or VPAC(2) also abolished circadian firing rhythms in approximately half of all SCN neurons

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  3. 03AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Mechanism

    In mice, loss of VIP or VPAC(2) disrupted synchrony between rhythmic SCN neurons.

    In plain wordsIn mice, loss of VIP or its receptor disrupted the timing match between clock neurons that still had a rhythm.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseSynchrony between rhythmic SCN neurons
    Study

    mousen: not reported in source

    Vip-/- and Vipr2-/- mice, suprachiasmatic nucleus neurons
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    disrupted synchrony between rhythmic neurons.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  4. 04AnimalNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneAnimal study (in vivo)Mechanism

    In VIP-/- SCN neurons, daily application of a VPAC(2) agonist restored rhythmicity and synchrony, but it did not in Vipr2-/- neurons.

    In plain wordsIn mice lacking VIP, a drug that activates the VIP receptor restored daily rhythm in clock neurons, but not in mice lacking the receptor.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseRescue of rhythmicity and synchrony by a VPAC(2) agonist
    Study

    mousen: not reported in source

    Vip-/- and Vipr2-/- mice, suprachiasmatic nucleus neurons
    Comparator
    Vipr2-/- neurons
    Outcome group
    Circadian rhythm · Nervous system and cognition

    Source sentences

    Summary
    Critically, daily application of a VPAC(2) agonist restored rhythmicity and synchrony to VIP(-/-) SCN neurons, but not to Vipr2(-/-) neurons.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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