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Study · Animal study (in vivo) · rat · 2005

5 results

Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections.

Zheng H, Patterson LM, Phifer CB, Berthoud HR

American journal of physiology. Regulatory, integrative and comparative physiology3 Mar 2005Cited by 138 (Europe PMC)

PMID15746303 (opens in a new tab)DOI10.1152/ajpregu.00869.2004 (opens in a new tab)PepBankPUB-15746303
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII injected into the fourth ventricle potently inhibited 14-h food intake.

    In plain wordsIn rats, MTII injected into the fourth brain ventricle strongly reduced food eaten over 14 hours.

    Peptide
    Melanotan II
    Outcome
    Decrease14-h food intake
    Study

    ratn: not reported in source

    rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · fourth ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Melanotan II (MTII), a stable melanocortin 4 receptor (MC4R) and melanocortin 3 receptor (MC3R) agonist injected into the fourth ventricle near the dorsal vagal complex, potently inhibited 14-h food intake by decreasing meal size but not meal frequency; SHU9119, an antagonist, increased food intake…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, fourth-ventricle MTII reduced 14-h food intake by decreasing meal size.

    In plain wordsIn rats, MTII reduced food intake by making meals smaller.

    Peptide
    Melanotan II
    Outcome
    DecreaseMeal size
    Study

    ratn: not reported in source

    rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · fourth ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Melanotan II (MTII), a stable melanocortin 4 receptor (MC4R) and melanocortin 3 receptor (MC3R) agonist injected into the fourth ventricle near the dorsal vagal complex, potently inhibited 14-h food intake by decreasing meal size but not meal frequency; SHU9119, an antagonist, increased food intake…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, fourth-ventricle MTII did not change meal frequency.

    In plain wordsIn rats, MTII did not change how often meals were eaten.

    Peptide
    Melanotan II
    Outcome
    No significant changeMeal frequency
    Study

    ratn: not reported in source

    rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · fourth ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Melanotan II (MTII), a stable melanocortin 4 receptor (MC4R) and melanocortin 3 receptor (MC3R) agonist injected into the fourth ventricle near the dorsal vagal complex, potently inhibited 14-h food intake by decreasing meal size but not meal frequency; SHU9119, an antagonist, increased food intake…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In freely moving rats, fourth-ventricle MTII increased heart rate measured by telemetry.

    In plain wordsIn rats, MTII injected into the fourth brain ventricle raised heart rate.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate
    Study

    ratn: not reported in source

    rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · fourth ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, MTII injected into the fourth ventricle increased and SHU9119 tended to decrease heart rate and body temperature measured telemetrically in freely moving rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In freely moving rats, fourth-ventricle MTII increased body temperature measured by telemetry.

    In plain wordsIn rats, MTII injected into the fourth brain ventricle raised body temperature.

    Peptide
    Melanotan II
    Outcome
    IncreaseBody temperature
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · fourth ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, MTII injected into the fourth ventricle increased and SHU9119 tended to decrease heart rate and body temperature measured telemetrically in freely moving rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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