Skip to content

Study · Non-randomized trial · n = 18 · 2005

2 results

Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow.

Takahashi PY, Liu PY, Roebuck PD, Iranmanesh A, Veldhuis JD

The Journal of clinical endocrinology and metabolism1 Mar 2005Cited by 15 (Europe PMC)

PMID15741251 (opens in a new tab)PMCIDPMC1236990 (opens in a new tab)DOI10.1210/jc.2004-2521 (opens in a new tab)PepBankPUB-15741251
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialMechanism

    In healthy men, increasing age attenuated ganirelix suppression of LH pulse size (r = -0.648, P = 0.004).

    In plain wordsIn healthy men, older age reduced ganirelix suppression of LH pulse size compared with younger age.

    Peptide
    Ganirelix
    Outcome
    DecreaseAge attenuation of LH pulse suppression
    Study

    n = 18

    Comparator
    younger age
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · subcutaneousAs given in this study (human).

    Measurements

    Correlation of age with ganirelix suppression of LH pulse size
    −0.648 r
    healthy men ages 23-72 yr

    Source sentences

    Summary
    Statistical analyses revealed that increasing age markedly attenuated the capability of ganirelix to decrease LH pulse size (viz., r = -0.648; P = 0.004).
    2 context sentences
    Summary · context
    To this end, blood was sampled every 10 min for 2 h before and 16 h after sc administration of saline or ganirelix
    Summary · context
    To assess the impact of age on central GnRH outflow indirectly, we quantitated graded suppression of pulsatile LH secretion by saline and escalating doses of a potent and selective GnRH-receptor antagonist, ganirelix, in 18 healthy men ages 23-72 yr.
  2. 02HumanNon-randomized trialMechanism

    In healthy men, age did not modify the competitive interaction between injected GnRH and ganirelix.

    In plain wordsIn healthy men, age did not change the competitive interaction between injected GnRH and ganirelix.

    Peptide
    Ganirelix
    Outcome
    No significant changeAge modification of GnRH-ganirelix interaction
    Study

    n = 18

    Comparator
    younger age
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    In contrast, age did not modify the competitive interaction between injected GnRH and ganirelix.
    1 context sentence
    Summary · context
    To assess the impact of age on central GnRH outflow indirectly, we quantitated graded suppression of pulsatile LH secretion by saline and escalating doses of a potent and selective GnRH-receptor antagonist, ganirelix, in 18 healthy men ages 23-72 yr.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.