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Study · Animal study (in vivo) · mouse · 2004

3 results

Effect of melatonin and tetrapeptide on gene expression in mouse brain.

Anisimov SV, Khavinson VKh, Anisimov VN

Bulletin of experimental biology and medicine1 Nov 2004Cited by 3 (Europe PMC)

PMID15723138 (opens in a new tab)DOI10.1007/s10517-005-0082-z (opens in a new tab)PepBankPUB-15723138
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mouse brain, Epithalon modified the expression of 22 transcripts, and melatonin modified 38.

    In plain wordsIn mice, Epithalon changed the activity of 22 genes in the brain.

    Peptide
    Epitalon
    Outcome
    MixedBrain transcripts with changed expression after Epithalon
    Study

    Mousen: not reported in source

    Comparator
    Melatonin
    Outcome group
    Aging markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Transcripts with changed expression
    22 transcripts
    Epithalon

    Source sentences

    Summary
    Melatonin and Epithalon modified expression of 38 and 22 transcripts, respectively.
    1 context sentence
    Summary · context
    A microchip technique was used to study expression of 16,897 clones from a cDNA library in the brain of mice receiving melatonin or tetrapeptide Epithalon (Ala-Glu-Asp-Gly).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mouse brain, Epithalon and melatonin produced similar changes in the expression of 6 transcripts.

    In plain wordsIn mice, Epithalon and melatonin changed the activity of the same 6 brain genes in a similar way.

    Peptide
    Epitalon
    Outcome
    MixedTranscripts changed similarly by Epithalon and melatonin
    Study

    Mousen: not reported in source

    Comparator
    Melatonin
    Outcome group
    Aging markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Transcripts with similar changes
    6 transcripts
    Epithalon and melatonin

    Source sentences

    Summary
    These preparations produced similar changes in the expression of 6 transcripts.
    1 context sentence
    Summary · context
    A microchip technique was used to study expression of 16,897 clones from a cDNA library in the brain of mice receiving melatonin or tetrapeptide Epithalon (Ala-Glu-Asp-Gly).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mouse brain, Epithalon induced expression of the transcript Rp119, which melatonin inhibited.

    In plain wordsIn mice, Epithalon raised the activity of the Rp119 gene in the brain, while melatonin lowered it.

    Peptide
    Epitalon
    Outcome
    IncreaseRp119 transcript expression
    Study

    Mousen: not reported in source

    Comparator
    Melatonin
    Outcome group
    Aging markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Expression of 1 transcript (Rp119) was inhibited by melatonin, but induced by Epithalon.
    1 context sentence
    Summary · context
    A microchip technique was used to study expression of 16,897 clones from a cDNA library in the brain of mice receiving melatonin or tetrapeptide Epithalon (Ala-Glu-Asp-Gly).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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