Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.

Coviello AD, Matsumoto AM, Bremner WJ, Herbst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP

The Journal of clinical endocrinology and metabolism15 Feb 2005Cited by 96 (Europe PMC)

PMID15713727DOI10.1210/jc.2004-0802PepBankPUB-15713727

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In healthy men with testosterone-induced gonadotropin suppression, ITT increased linearly with increasing hCG dose.
In plain wordsIn healthy men with suppressed gonadotropins, higher hCG doses produced higher testosterone inside the testes.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseIntratesticular testosterone dose response
Study
n = 29
Comparator
Lower hCG doses
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
125, 250, or 500 IU every other day · 3 wkAs given in this study (human).
Measurements
P value for linear ITT dose response
< 0.001 P value
ITT versus increasing hCG dose
Source sentences
Summary
ITT increased linearly with increasing hCG dose (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk.
Report a problemFND-1571372701
02HumanRandomized controlled trialEfficacy outcome
In healthy men receiving testosterone enanthate, ITT after 125 IU hCG was 25% below baseline.
In plain wordsIn healthy men receiving testosterone, testicular testosterone with 125 IU hCG was 25% below baseline.
Peptide
hCG (human chorionic gonadotropin)
Outcome
DecreaseITT at 125 IU
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
125 IU every other day · 3 wkAs given in this study (human).
Measurements
Posttreatment ITT less than baseline
25%
Testosterone enanthate with 125 IU hCG, posttreatment versus baseline
Source sentences
Summary
Posttreatment ITT was 25% less than baseline in the 125 IU hCG group
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk.
Report a problemFND-1571372702
03HumanRandomized controlled trialEfficacy outcome
In healthy men receiving testosterone enanthate, ITT after 250 IU hCG was 7% below baseline.
In plain wordsIn healthy men receiving testosterone, testicular testosterone with 250 IU hCG was 7% below baseline.
Peptide
hCG (human chorionic gonadotropin)
Outcome
DecreaseITT at 250 IU
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
250 IU every other day · 3 wkAs given in this study (human).
Measurements
Posttreatment ITT less than baseline
7%
Testosterone enanthate with 250 IU hCG, posttreatment versus baseline
Source sentences
Summary
Posttreatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk.
Report a problemFND-1571372703
04HumanRandomized controlled trialEfficacy outcome
In healthy men receiving testosterone enanthate, ITT after 500 IU hCG was 26% above baseline.
In plain wordsIn healthy men receiving testosterone, testicular testosterone with 500 IU hCG was 26% above baseline.
Peptide
hCG (human chorionic gonadotropin)
Outcome
IncreaseITT at 500 IU
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
500 IU every other day · 3 wkAs given in this study (human).
Measurements
Posttreatment ITT greater than baseline
26%
Testosterone enanthate with 500 IU hCG, posttreatment versus baseline
Source sentences
Summary
Posttreatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk.
Report a problemFND-1571372704