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Study · Animal study (in vivo) · rat · 2005

4 results

Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by mu and kappa opioid receptors.

Zubrzycka M, Fichna J, Janecka A

Brain research1 Feb 2005Cited by 14 (Europe PMC)

PMID15713278 (opens in a new tab)DOI10.1016/j.brainres.2004.11.045 (opens in a new tab)PepBankPUB-15713278
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular oxytocin showed a significant analgesic effect, measured as reduced amplitude of the tongue retractory movements after tooth pulp stimulation.

    In plain wordsIn rats, oxytocin injected into the brain ventricles reduced the pain reflex of the tongue.

    Peptide
    Oxytocin
    Outcome
    DecreaseTrigemino-hypoglossal reflex (antinociception)
    Study

    ratn: not reported in source

    Trigemino-hypoglossal reflex after tooth pulp stimulation
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    With the experimental settings used in this study, we have demonstrated that oxytocin showed significant analgesic effect after intracerebroventricular administration in rats, as assayed by the amplitude of the retractory movements of the tongue after tooth pulp stimulation.
    1 context sentence
    Summary · context
    The present study was undertaken to investigate the effect of oxytocin on trigemino-hypoglossal reflex in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, co-administration of oxytocin with endomorphin-2 did not significantly increase the antinociceptive activity of endomorphin-2.

    In plain wordsIn rats, adding oxytocin to endomorphin-2 did not significantly increase the pain-relieving effect of endomorphin-2 alone.

    Peptide
    Oxytocin
    Outcome
    No significant changeAntinociception of endomorphin-2 with oxytocin
    Study

    ratn: not reported in source

    Trigemino-hypoglossal reflex after tooth pulp stimulation
    Comparator
    Endomorphin-2 alone
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Co-administration of oxytocin and a mu-selective endogenous opioid ligand endomorphin-2 did not significantly increase the antinociceptive activity of endomorphin-2.
    1 context sentence
    Summary · context
    The present study was undertaken to investigate the effect of oxytocin on trigemino-hypoglossal reflex in rats.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, the oxytocin antagonist atosiban inhibited the antinociceptive effect of oxytocin.

    In plain wordsIn rats, a drug that blocks the oxytocin receptor reduced the pain-relieving effect of oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin antinociception with atosiban
    Study

    ratn: not reported in source

    Trigemino-hypoglossal reflex after tooth pulp stimulation
    Comparator
    Oxytocin alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Antinociceptive effect of oxytocin was inhibited by subsequent perfusion of cerebral ventricles with oxytocin antagonist, [deamino-Cys1-D-Tyr(OEt)2-Thr4-Orn8]-oxytocin, atosiban.
    1 context sentence
    Summary · context
    The present study was undertaken to investigate the effect of oxytocin on trigemino-hypoglossal reflex in rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In rats, the inhibition of oxytocin antinociception by opioid antagonists was mediated through mu and kappa opioid receptors.

    In plain wordsIn rats, blocking mu and kappa opioid receptors reduced the pain-relieving effect of oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin antinociception with opioid antagonists
    Study

    ratn: not reported in source

    Trigemino-hypoglossal reflex after tooth pulp stimulation
    Comparator
    Oxytocin alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    It was shown that inhibition of antinociceptive effects was mediated through mu and kappa opioid receptors, indicating that there is a synergy between oxytocin and opioid systems in transmitting and modulating pain stimuli.
    1 context sentence
    Summary · context
    The present study was undertaken to investigate the effect of oxytocin on trigemino-hypoglossal reflex in rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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