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Study · Non-randomized trial · n = 7 · 2005

3 results

Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.

Laferrère B, Abraham C, Russell CD, Bowers CY

The Journal of clinical endocrinology and metabolism1 Feb 2005Cited by 40 (Europe PMC)

PMID15699539 (opens in a new tab)PMCIDPMC2824650 (opens in a new tab)DOI10.1210/jc.2004-1719 (opens in a new tab)PepBankPUB-15699539
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In lean, healthy men, subcutaneous GHRP‑2 infusion increased intake of an ad libitum meal by 35.9% versus saline.

    In plain wordsIn healthy men, GHRP‑2 infusion made them eat more at a buffet meal than saline did.

    Peptide
    GHRP-2
    Outcome
    IncreaseAd libitum meal intake
    Study

    n = 7

    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 microg/kg/h · subcutaneous · 270 minutesAs given in this study (human).

    Measurements

    Increase in meal intake
    35.9%
    GHRP-2 vs saline

    Source sentences

    Summary
    Similar to what has been reported for ghrelin administration, our subjects ate 35.9 +/- 10.9% more when infused with GHRP-2 vs. saline, with every subject increasing their intake even when calculated per kg body weight (136.0 +/- 13.0 kJ/kg [32.5 +/- 3.1 kcal/kg] vs. 101.3 +/- 10.5 kJ/kg [24.2 +/- 2…
    1 context sentence
    Summary · context
    We subcutaneously infused 7 lean, healthy males with GHRP-2 (1 microg/kg/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal.
  2. 02HumanNon-randomized trialEfficacy outcome

    In lean, healthy men, the macronutrient composition of the meal did not differ between GHRP‑2 and saline infusion.

    In plain wordsIn healthy men, the mix of nutrients they ate was the same with GHRP‑2 as with saline.

    Peptide
    GHRP-2
    Outcome
    No significant changeMacronutrient composition of meal
    Study

    n = 7

    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1 microg/kg/h · subcutaneous · 270 minutesAs given in this study (human).

    Source sentences

    Summary
    The macronutrient composition of consumed food was not different between conditions.
    1 context sentence
    Summary · context
    We subcutaneously infused 7 lean, healthy males with GHRP-2 (1 microg/kg/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal.
  3. 03HumanNon-randomized trialEfficacy outcome

    In lean, healthy men, serum GH levels rose significantly during GHRP‑2 infusion compared with saline.

    In plain wordsIn healthy men, blood growth hormone levels rose during GHRP‑2 infusion compared with saline.

    Peptide
    GHRP-2
    Outcome
    IncreaseSerum GH level (AUC)
    Study

    n = 7

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg/h · subcutaneous · 270 minutesAs given in this study (human).

    Measurements

    Serum GH AUC
    5550 microg/L/240 min
    GHRP-2
    Serum GH AUC
    412 microg/L/240 min
    saline

    Source sentences

    Summary
    As expected, serum GH levels rose significantly during GHRP-2 infusion (AUC 5550 +/- 1090 microg/L/240 min vs. 412 +/- 161 microg/L/240 min, p = 0.003).
    1 context sentence
    Summary · context
    We subcutaneously infused 7 lean, healthy males with GHRP-2 (1 microg/kg/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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