In vitro and in vivo induction of heme oxygenase 1 in mouse macrophages following melanocortin receptor activation.

Lam CW, Getting SJ, Perretti M

Journal of immunology (Baltimore, Md. : 1950)1 Feb 2005Cited by 39 (Europe PMC)

PMID15699165DOI10.4049/jimmunol.174.4.2297PepBankPUB-15699165

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In mice, in vivo administration of MTII induced HO-1 in peritoneal macrophages.
In plain wordsIn mice, giving MTII raised the level of the protein HO-1 in immune cells of the belly cavity.
Peptide
Melanotan II
Outcome
IncreaseHO-1 induction in peritoneal macrophages after in vivo MTII
Study
mousen: not reported in source
peritoneal macrophages after in vivo administration
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
HO-1 induction in peritoneal Mphi was also detected following in vivo administration of MTII
Report a problemFND-1569916504
02AnimalAnimal study (in vivo)Mechanism
In mice, the antimigratory effect of MTII appeared to be functionally related to HO-1 induction, as tested with an HO inhibitor.
In plain wordsIn mice, MTII reduced the movement of immune cells, and this seemed linked to the protein HO-1.
Peptide
Melanotan II
Outcome
DecreaseMacrophage migration (antimigratory effect)
Study
mousen: not reported in source
peritoneal macrophages after in vivo administration
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
HO-1 induction in peritoneal Mphi was also detected following in vivo administration of MTII, and appeared to be functionally related to the antimigratory effect of this melanocortin, as determined with a specific inhibitor (zinc protoporphyrin IX).
Report a problemFND-1569916505
03LabIn vitro (cells)Mechanism
In primary mouse peritoneal macrophages, MTII incubation induced HO-1 expression.
In plain wordsIn mouse immune cells grown in the lab, MTII raised the level of the protein HO-1.
Peptide
Melanotan II
Outcome
IncreaseHO-1 expression in primary peritoneal macrophages
Study
mousen: not reported in source
primary peritoneal macrophages
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Relevantly, ACTH and MTII incubation with primary peritoneal macrophages (Mphi) also induced HO-1 expression.
Report a problemFND-1569916502
04LabIn vitro (cells)Mechanism
In mouse RAW264.7 macrophages, MTII produced a concentration-dependent accumulation of cAMP.
In plain wordsIn mouse immune cells grown in the lab, MTII raised cAMP in step with its concentration.
Peptide
Melanotan II
Outcome
IncreasecAMP accumulation in RAW264.7 cells
Study
mousen: not reported in source
RAW264.7 macrophages
Outcome group
Receptor activity and mechanism · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
ACTH and MTII produced a concentration-dependent accumulation of cAMP
Report a problemFND-1569916503

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

05LabNot a test of Melanotan II aloneIn vitro (cells)Mechanism
In mouse RAW264.7 macrophages, selective melanocortin agonists including melanotan (MTII) indicated a predominant role for MC3-R in the induction of HO-1 expression and activity.
In plain wordsIn mouse immune cells, several selective melanocortin drugs, including melanotan, raised the stress-protein HO-1, mainly through one receptor.
Peptide
Melanotan II
Outcome
IncreaseHO-1 induction by selective melanocortin agonists
Study
mousen: not reported in source
RAW264.7 macrophages
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
However, use of more selective agonists (including melanotan (MTII)) indicated a predominant role for MC3-R in the induction of HO-1 expression and activity.
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-1569916501
06LabNot a test of Melanotan II aloneIn vitro (cells)Mechanism
In mouse macrophages, a selective inhibitor of cAMP-dependent protein kinase A abrogated ACTH- and MTII-induced HO-1 expression.
In plain wordsIn mouse immune cells grown in the lab, blocking a cAMP-dependent enzyme stopped MTII and ACTH from raising the protein HO-1.
Peptide
Melanotan II
Outcome
DecreaseEffect of a protein kinase A inhibitor on MTII-induced HO-1 expression
Study
mousen: not reported in source
Outcome group
Receptor activity and mechanism · Immune and inflammation
Source sentences
Summary
a selective inhibitor of cAMP-dependent protein kinase A abrogated ACTH- and MTII-induced HO-1 expression
In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.
Report a problemFND-1569916506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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