Skip to content

Study · In vitro (cells) · 2005

2 results

Vasotocin and vasopressin stimulation of the chloride secretion in the human bronchial epithelial cell line, 16HBE14o-.

Bernard K, Bogliolo S, Ehrenfeld J

British journal of pharmacology1 Apr 2005Cited by 64 (Europe PMC)

PMID15685210 (opens in a new tab)PMCIDPMC1576086 (opens in a new tab)DOI10.1038/sj.bjp.0706103 (opens in a new tab)PepBankPUB-15685210
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, basolateral oxytocin induced a transient short-circuit current stimulation, which arginine vasopressin did not.

    In plain wordsIn lab-grown human airway cells, oxytocin triggered a short rise in chloride secretion current, while vasopressin did not.

    Peptide
    Oxytocin
    Outcome
    IncreaseTransient short-circuit current (I(peak)) stimulation
    Study

    humann: not reported in source

    16HBE14o- bronchial epithelial cell line
    Comparator
    Arginine vasopressin
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · basolateral applicationAs given in this study (human).

    Source sentences

    Summary
    In symmetrical Cl(-) solutions, basolateral application of arginine vasotocin (AVT), oxytocin or isotocin induced a transient I(sc) stimulation (I(peak)), whereas arginine vasopressin (AVP) did not.
    1 context sentence
    Summary · context
    Using the 16HBE14o- bronchial epithelial cell line, we investigated their action on Cl(-) secretion.
  2. 02LabIn vitro (cells)Activity measurement

    In human bronchial epithelial cells, the efficacy order for the peak current was arginine vasotocin above oxytocin above isotocin, far above arginine vasopressin.

    In plain wordsIn lab-grown human airway cells, oxytocin was less effective than vasotocin but more effective than isotocin and vasopressin at triggering the current.

    Peptide
    Oxytocin
    Outcome
    Not applicableEfficacy order for I(peak) stimulation
    Study

    humann: not reported in source

    16HBE14o- bronchial epithelial cell line
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These results point to the stimulation of a V1-like receptor mediating I(peak) and presenting an efficacy order, AVT>oxytocin>isotocin>>AVP.
    1 context sentence
    Summary · context
    Using the 16HBE14o- bronchial epithelial cell line, we investigated their action on Cl(-) secretion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.