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Study · Not a test of the peptide alone · 2005

1 result

Insulin-like growth factor-I down-regulates ghrelin receptor (growth hormone secretagogue receptor) expression in the rat pituitary.

Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Oikawa S

Regulatory peptides1 Apr 2005Cited by 25 (Europe PMC)

PMID15680488 (opens in a new tab)DOI10.1016/j.regpep.2004.12.001 (opens in a new tab)PepBankPUB-15680488
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In rat pituitary cell cultures, pretreatment with IGF-I significantly reduced the GH response to KP-102.

    In plain wordsIn rat pituitary cells, IGF-I pretreatment lowered the growth hormone release caused by KP-102.

    Peptide
    GHRP-2
    Outcome
    DecreaseGH response to KP-102 after IGF-I pretreatment
    Study

    ratn: not reported in source

    Rat pituitary cell cultures
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    however, the GH response to the receptor ligand, a synthetic GHS, KP-102 (100 nM, 15 min), was significantly reduced by pretreatment with IGF-I.
    1 context sentence
    Summary · context
    The effects of insulin-like growth factor-I (IGF-I) on the ghrelin receptor [growth hormone secretagogue receptor (GHS-R)] gene expression and on the GH response to GHS in rat pituitary cell cultures were examined.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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