Leptin-like effects of MTII are augmented in MSG-obese rats.

Kim YW, Choi DW, Park YH, Huh JY, Won KC, Choi KH, Park SY, Kim JY, Lee SK

Regulatory peptides1 Apr 2005Cited by 12 (Europe PMC)

PMID15680471DOI10.1016/j.regpep.2004.10.006PepBankPUB-15680471

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In MSG-obese rats, intracerebroventricular MTII infusion decreased food intake compared with aCSF-infused rats.
In plain wordsIn obese rats, MTII infused into the brain reduced food intake compared with rats given a control fluid.
Peptide
Melanotan II
Outcome
DecreaseFood intake
Study
ratn: not reported in source
monosodium glutamate (MSG)-induced obese rats
Comparator
aCSF-infused rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 1 weekAs given in this study (rat).
Source sentences
Summary
The infusion of MTII decreased their food intake, visceral fat, and body weight in MSG-obese rats compared with aCSF-infused rats.
2 context sentences(design, population, supporting numbers)
Summary · context
MTII, or artificial cerebrospinal fluid (aCSF), was infused into i.c.v. with an osmotic minipump for 1 week.
Summary · context
MSG-obese rats were induced by neonatal injection of MSG.
Report a problemFND-1568047101
02AnimalAnimal study (in vivo)Efficacy outcome
In MSG-obese rats, MTII infusion decreased visceral fat compared with aCSF-infused rats.
In plain wordsIn obese rats, MTII infused into the brain reduced belly fat compared with rats given a control fluid.
Peptide
Melanotan II
Outcome
DecreaseVisceral fat
Study
ratn: not reported in source
monosodium glutamate (MSG)-induced obese rats
Comparator
aCSF-infused rats
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 1 weekAs given in this study (rat).
Source sentences
Summary
The infusion of MTII decreased their food intake, visceral fat, and body weight in MSG-obese rats compared with aCSF-infused rats.
2 context sentences(design, population, supporting numbers)
Summary · context
MTII, or artificial cerebrospinal fluid (aCSF), was infused into i.c.v. with an osmotic minipump for 1 week.
Summary · context
MSG-obese rats were induced by neonatal injection of MSG.
Report a problemFND-1568047102
03AnimalAnimal study (in vivo)Efficacy outcome
In MSG-obese rats, MTII infusion decreased body weight compared with aCSF-infused rats.
In plain wordsIn obese rats, MTII infused into the brain lowered body weight compared with rats given a control fluid.
Peptide
Melanotan II
Outcome
DecreaseBody weight
Study
ratn: not reported in source
monosodium glutamate (MSG)-induced obese rats
Comparator
aCSF-infused rats
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 1 weekAs given in this study (rat).
Source sentences
Summary
The infusion of MTII decreased their food intake, visceral fat, and body weight in MSG-obese rats compared with aCSF-infused rats.
2 context sentences(design, population, supporting numbers)
Summary · context
MTII, or artificial cerebrospinal fluid (aCSF), was infused into i.c.v. with an osmotic minipump for 1 week.
Summary · context
MSG-obese rats were induced by neonatal injection of MSG.
Report a problemFND-1568047103
04AnimalAnimal study (in vivo)Efficacy outcome
In MSG-obese rats, MTII treatment increased oxygen consumption compared with aCSF-infused and pair-fed rats.
In plain wordsIn obese rats, MTII raised oxygen use compared with control-fluid rats and rats fed the same amount of food.
Peptide
Melanotan II
Outcome
IncreaseOxygen consumption
Study
ratn: not reported in source
monosodium glutamate (MSG)-induced obese rats
Comparator
aCSF-infused and pair-fed rats
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 1 weekAs given in this study (rat).
Source sentences
Summary
The oxygen consumption was increased by MTII treatment in MSG-obese rats compared with aCSF as well as pair fed (PF) rats.
2 context sentences(design, population, supporting numbers)
Summary · context
MTII, or artificial cerebrospinal fluid (aCSF), was infused into i.c.v. with an osmotic minipump for 1 week.
Summary · context
MSG-obese rats were induced by neonatal injection of MSG.
Report a problemFND-1568047104
05AnimalAnimal study (in vivo)Efficacy outcome
The leptin-like effects of MTII were greater in MSG-obese rats than in control rats.
In plain wordsIn rats, the leptin-like effects of MTII were stronger in obese rats than in control rats.
Peptide
Melanotan II
Outcome
IncreaseSize of MTII effects in MSG-obese versus control rats
Study
ratn: not reported in source
monosodium glutamate (MSG)-induced obese rats
Comparator
Control rats
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricular · 1 weekAs given in this study (rat).
Source sentences
Summary
Interestingly, these leptin-like effects of MTII were greater in MSG-obese rats than in controls
2 context sentences(design, population, supporting numbers)
Summary · context
MTII, or artificial cerebrospinal fluid (aCSF), was infused into i.c.v. with an osmotic minipump for 1 week.
Summary · context
MSG-obese rats were induced by neonatal injection of MSG.
Report a problemFND-1568047105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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