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Study · Animal study (in vivo) · rhesus monkey (macaca mulatta) · 2005

7 results

Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.

Goncharova ND, Vengerin AA, Khavinson VKh, Lapin BA

Experimental gerontology1 Jan 2005Cited by 15 (Europe PMC)

PMID15664732 (opens in a new tab)DOI10.1016/j.exger.2004.10.004 (opens in a new tab)PepBankPUB-15664732
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon administration decreased basal plasma glucose levels.

    In plain wordsIn old monkeys, epitalon lowered basal blood glucose.

    Peptide
    Epitalon
    Outcome
    DecreaseBasal plasma glucose
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The epitalon administration to old monkeys caused the decrease in the basal levels of glucose and insulin and the increase in the basal night melatonin level.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon administration decreased basal plasma insulin levels.

    In plain wordsIn old monkeys, epitalon lowered basal blood insulin.

    Peptide
    Epitalon
    Outcome
    DecreaseBasal plasma insulin
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The epitalon administration to old monkeys caused the decrease in the basal levels of glucose and insulin and the increase in the basal night melatonin level.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon administration increased the basal night melatonin level.

    In plain wordsIn old monkeys, epitalon raised the night melatonin level.

    Peptide
    Epitalon
    Outcome
    IncreaseBasal night melatonin level
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The epitalon administration to old monkeys caused the decrease in the basal levels of glucose and insulin and the increase in the basal night melatonin level.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon decreased the area under the plasma glucose response curve after glucose administration.

    In plain wordsIn old monkeys, epitalon lowered the blood glucose rise after a glucose dose.

    Peptide
    Epitalon
    Outcome
    DecreaseArea under the plasma glucose response curve after glucose load
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, in the case of old monkeys, epitalon decreased the area under the plasma glucose response curve, markedly increased the glucose 'disappearance' rate and normalized the plasma insulin dynamics in response to glucose administration.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon markedly increased the glucose disappearance rate after glucose administration.

    In plain wordsIn old monkeys, epitalon sped up the removal of glucose from blood after a glucose dose.

    Peptide
    Epitalon
    Outcome
    IncreaseGlucose disappearance rate
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, in the case of old monkeys, epitalon decreased the area under the plasma glucose response curve, markedly increased the glucose 'disappearance' rate and normalized the plasma insulin dynamics in response to glucose administration.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In old rhesus monkeys, epitalon normalized the plasma insulin dynamics in response to glucose administration.

    In plain wordsIn old monkeys, epitalon brought the insulin response to a glucose dose back toward normal.

    Peptide
    Epitalon
    Outcome
    Direction not reportedPlasma insulin dynamics after glucose load
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, in the case of old monkeys, epitalon decreased the area under the plasma glucose response curve, markedly increased the glucose 'disappearance' rate and normalized the plasma insulin dynamics in response to glucose administration.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In young rhesus monkeys, epitalon did not affect the hormonal and metabolic parameters.

    In plain wordsIn young monkeys, epitalon did not change hormone or metabolic measures.

    Peptide
    Epitalon
    Outcome
    No significant changeHormonal and metabolic parameters in young monkeys
    Study

    Rhesus monkey (Macaca mulatta)n: not reported in source

    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Yet, it has not affected the hormonal and metabolic changes in young animals.
    1 context sentence
    Summary · context
    The purpose of this research was to study age-related changes in functioning of pineal and pancreatic glands of non-human primates, rhesus monkeys, and to elucidate the possibility of their corrections with the help of epitalon, a synthetic analogue of the pharmacopoeia drug epithalamin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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