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Study · Animal study (in vivo) · rat · 2005

2 results

Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript peptide.

Yang SC, Shieh KR

Journal of neurochemistry1 Feb 2005Cited by 18 (Europe PMC)

PMID15659233 (opens in a new tab)DOI10.1111/j.1471-4159.2004.02896.x (opens in a new tab)PepBankPUB-15659233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In female rats, MT II at 10 microg increased DOPAC levels in the nucleus accumbens, similar to CART peptide.

    In plain wordsIn female rats, MT II raised a dopamine breakdown marker in a brain reward area, as CART peptide did.

    Peptide
    Melanotan II
    Outcome
    IncreaseDOPAC level in nucleus accumbens
    Study

    ratn: not reported in source

    female Sprague-Dawley rats
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 microgAs given in this study (rat).

    Source sentences

    Summary
    We found that the agonist of alpha-melanocyte stimulating hormone (alpha-MSH), MT II, at 10 microg had a stimulatory effect on the NA and ST DOPAC levels similar to the CART peptide.
    1 context sentence
    Summary · context
    Stimulatory effects of cocaine- and amphetamine-regulated transcript (CART) peptide on central mesolimbic, nigrostriatal and mesocortical dopaminergic (DA) neurons were examined in female Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In female rats, MT II at 10 microg increased DOPAC levels in the striatum, similar to CART peptide.

    In plain wordsIn female rats, MT II raised a dopamine breakdown marker in the striatum, as CART peptide did.

    Peptide
    Melanotan II
    Outcome
    IncreaseDOPAC level in striatum
    Study

    ratn: not reported in source

    female Sprague-Dawley rats
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    10 microgAs given in this study (rat).

    Source sentences

    Summary
    We found that the agonist of alpha-melanocyte stimulating hormone (alpha-MSH), MT II, at 10 microg had a stimulatory effect on the NA and ST DOPAC levels similar to the CART peptide.
    1 context sentence
    Summary · context
    Stimulatory effects of cocaine- and amphetamine-regulated transcript (CART) peptide on central mesolimbic, nigrostriatal and mesocortical dopaminergic (DA) neurons were examined in female Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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