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Study · Animal study (in vivo) · mouse · 2004

5 results

[Neonatal Semax and saline injections induce open-field behavior changes in mice of different genotypes].

Shilova OB, Markina NV, Perepelkina OV, Gichenok IV, Korochkin LI, Poletaeva II

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Nov 2004Cited by 1 (Europe PMC)

PMID15658043 (opens in a new tab)PepBankPUB-15658043
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult mice injected as neonates with Semax, the open-field behavior changed compared with intact mice, as it did after saline injections.

    In plain wordsIn mice, neonatal Semax injections changed behavior in adulthood compared with untreated mice, as saline injections also did.

    Peptide
    Semax
    Outcome
    MixedOpen-field behavior in adult mice
    Study

    mousen: not reported in source

    DBA/2, CBA, F1 hybrid, 101/HY and C3H mice
    Comparator
    Intact mice
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    7 microg per animal · subcutaneous · neonatal days 2-7 of lifeAs given in this study (mouse).

    Source sentences

    Summary
    The common feature of remote effects of both Semax and saline injections was the set of changes in the open-field behavior in adult (2.5- to 3-month-old) animals as compared to intact mice.
    1 context sentence
    Summary · context
    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    After neonatal Semax or saline injections, freezing, grooming and rearing scores shifted in a genotype-dependent way in DBA/2 and C3H mice, and hole-poke frequencies in CBA and C3H mice.

    In plain wordsIn mice, behavior changes after early Semax or saline injections depended on the mouse genotype.

    Peptide
    Semax
    Outcome
    MixedGenotype-dependent shifts in freezing, grooming, rearing and hole-poke scores
    Study

    mousen: not reported in source

    DBA/2, CBA, F1 hybrid, 101/HY and C3H mice
    Comparator
    Intact mice
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    7 microg per animal · subcutaneous · neonatal days 2-7 of lifeAs given in this study (mouse).

    Source sentences

    Summary
    The most conspicuous shifts (genotype-dependent increase or decline) in freezing, grooming and rearing scores were displayed by DBA/2 and C3H mice, whereas the hole-poke frequencies were significantly changed in CBA and C3H mice.
    1 context sentence
    Summary · context
    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In DBA/2 mice, squares crossed in the center and rearing number in the Semax-injected group stayed approximately equal to intact mice, whereas both increased in the saline group.

    In plain wordsIn mice, Semax-injected animals stayed at the level of untreated mice, while saline-injected animals showed more activity.

    Peptide
    Semax
    Outcome
    No significant changeSquares crossed in the center and rearing number in DBA/2 mice
    Study

    mousen: not reported in source

    DBA/2, CBA, F1 hybrid, 101/HY and C3H mice
    Comparator
    Intact mice and saline-injected mice
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    7 microg per animal · subcutaneous · neonatal days 2-7 of lifeAs given in this study (mouse).

    Source sentences

    Summary
    Squares crossed in the center of arena and rearing number were significantly increased in saline group of DBA/2 mice, whereas in Semax-injected DBA/2 group they were approximately equal to the level of intact mice.
    1 context sentence
    Summary · context
    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In DBA/2 mice, the numbers of freezing and grooming episodes were also increased in the saline and Semax-injected groups.

    In plain wordsIn mice, the number of freezing and grooming episodes was also higher after both saline and Semax injections.

    Peptide
    Semax
    Outcome
    IncreaseFreezing and grooming episodes in DBA/2 mice
    Study

    mousen: not reported in source

    DBA/2, CBA, F1 hybrid, 101/HY and C3H mice
    Comparator
    Intact mice
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    7 microg per animal · subcutaneous · neonatal days 2-7 of lifeAs given in this study (mouse).

    Source sentences

    Summary
    At the same time, the numbers of freezing and grooming episodes were also increased in these groups.
    2 context sentences
    Summary · context
    whereas in Semax-injected DBA/2 group they were approximately equal to the level of intact mice
    Summary · context
    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice of other genotypes, the same open-field indices changed after neonatal injections, but the direction of change differed.

    In plain wordsIn mice of other genotypes, early injections also changed behavior, but in different directions.

    Peptide
    Semax
    Outcome
    MixedOpen-field indices in mice of other genotypes
    Study

    mousen: not reported in source

    DBA/2, CBA, F1 hybrid, 101/HY and C3H mice
    Comparator
    Intact mice
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    7 microg per animal · subcutaneous · neonatal days 2-7 of lifeAs given in this study (mouse).

    Source sentences

    Summary
    In mice of other genotypes, changes in the same indices of the open-field behavior were revealed, but these changes were different in their direction.
    1 context sentence
    Summary · context
    DBA/2, CBA mice, and their F1 hybrids (first series) and 101/HY and C3H mice (second series) were injected as neonates (2-7 days of life) with Semax (sc., 7 microg per animal).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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