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Study · Animal study (in vivo) · mouse · 2005

10 results

Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin.

Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E

Journal of neural transmission (Vienna, Austria : 1996)7 Jul 2004Cited by 36 (Europe PMC)

PMID15657642 (opens in a new tab)DOI10.1007/s00702-004-0181-4 (opens in a new tab)PepBankPUB-15657642
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In APP transgenic mice, Cerebrolysin decreased vascular amyloid deposition in a time-dependent manner versus saline.

    In plain wordsIn mice, Cerebrolysin reduced amyloid around blood vessels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseVascular amyloid deposition
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    Neuropathological analysis with an antibody against Abeta showed that Cbl decreased amyloid deposition around the blood vessels in a time dependent manner.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In APP transgenic mice, Cerebrolysin reduced perivascular microgliosis versus saline.

    In plain wordsIn mice, Cerebrolysin reduced microgliosis around blood vessels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePerivascular microgliosis
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    These effects were accompanied by a reduction in perivascular microgliosis and astrogliosis and increased expression of markers of vascular fitness such as CD31 and ZO-1.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In APP transgenic mice, Cerebrolysin reduced perivascular astrogliosis versus saline.

    In plain wordsIn mice, Cerebrolysin reduced astrogliosis around blood vessels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePerivascular astrogliosis
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    These effects were accompanied by a reduction in perivascular microgliosis and astrogliosis and increased expression of markers of vascular fitness such as CD31 and ZO-1.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In APP transgenic mice, Cerebrolysin increased CD31 expression versus saline.

    In plain wordsIn mice, Cerebrolysin increased the vascular marker CD31 compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCD31 expression
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    These effects were accompanied by a reduction in perivascular microgliosis and astrogliosis and increased expression of markers of vascular fitness such as CD31 and ZO-1.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In APP transgenic mice, Cerebrolysin increased ZO-1 expression versus saline.

    In plain wordsIn mice, Cerebrolysin increased the vascular marker ZO-1 compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseZO-1 expression
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    These effects were accompanied by a reduction in perivascular microgliosis and astrogliosis and increased expression of markers of vascular fitness such as CD31 and ZO-1.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  6. 06AnimalAnimal study (in vivo)Other

    In APP transgenic mice, no lymphocytic infiltration associated with vascular Abeta was observed.

    In plain wordsIn mice, researchers observed no lymphocyte infiltration associated with amyloid in blood vessels.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableVessel-associated lymphocytic infiltration
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    No lymphocytic infiltration was observed associated with Abeta in the vessels.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In APP transgenic mice, Cerebrolysin reduced endothelial cell subcellular alterations versus saline.

    In plain wordsIn mice, Cerebrolysin reduced endothelial cell damage compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEndothelial cell subcellular alterations
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    in Cbl-treated mice there was considerable reduction in the subcellular alterations of endothelial and smooth muscle cells with preservation of basal membranes and intercellular junctions.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In APP transgenic mice, Cerebrolysin reduced smooth muscle cell subcellular alterations versus saline.

    In plain wordsIn mice, Cerebrolysin reduced smooth muscle cell damage compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSmooth muscle cell subcellular alterations
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    in Cbl-treated mice there was considerable reduction in the subcellular alterations of endothelial and smooth muscle cells with preservation of basal membranes and intercellular junctions.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In APP transgenic mice, Cerebrolysin preserved basal membranes compared with saline-associated vascular damage.

    In plain wordsIn mice, Cerebrolysin preserved basal membranes compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBasal membrane preservation
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    in Cbl-treated mice there was considerable reduction in the subcellular alterations of endothelial and smooth muscle cells with preservation of basal membranes and intercellular junctions.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In APP transgenic mice, Cerebrolysin preserved intercellular junctions compared with saline-associated vascular damage.

    In plain wordsIn mice, Cerebrolysin preserved intercellular junctions compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseIntercellular junction preservation
    Study

    mousen: not reported in source

    Thy1 mutant human APP transgenic mice
    Comparator
    saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · three monthsAs given in this study (mouse).

    Source sentences

    Summary
    in Cbl-treated mice there was considerable reduction in the subcellular alterations of endothelial and smooth muscle cells with preservation of basal membranes and intercellular junctions.
    1 context sentence
    Summary · context
    To this end, tg mice expressing mutant human amyloid precursor protein (APP) under the Thy1 promoter were treated with Cbl or saline alone starting at 7 or 12 months of age for a total of three months.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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