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Study · In vitro (cells) · 2005

5 results

Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts.

Pollard JD, Quan S, Kang T, Koch RJ

Archives of facial plastic surgery1 Jan 2005Cited by 40 (Europe PMC)

PMID15655171 (opens in a new tab)DOI10.1001/archfaci.7.1.27 (opens in a new tab)PepBankPUB-15655171
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In normal human dermal fibroblasts, population-doubling times with GHK‑Cu were faster than in nontreated controls.

    In plain wordsIn cells, normal fibroblasts treated with GHK‑Cu doubled faster than untreated fibroblasts.

    Peptide
    GHK-Cu
    Outcome
    DecreasePopulation-doubling time of normal fibroblasts
    Study

    humann: not reported in source

    Primary human dermal fibroblasts (normal and irradiated), serum-free medium
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 x 10(-9) mol/LAs given in this study (human).

    Source sentences

    Summary
    The population-doubling times of normal and irradiated fibroblasts exposed to GHK-Cu were faster than those of nontreated controls.
    2 context sentences
    Summary · context
    Primary human dermal fibroblast cell lines were established after explantation from intraoperative specimens obtained from patients who had undergone radiation therapy for head and neck cancer.
    Summary · context
    Treatment groups were exposed to GHK-Cu (1 x 10(-9) mol/L).
  2. 02LabIn vitro (cells)Efficacy outcome

    In irradiated human dermal fibroblasts, population-doubling times with GHK‑Cu were faster than in nontreated controls.

    In plain wordsIn cells, irradiated fibroblasts treated with GHK‑Cu doubled faster than untreated fibroblasts.

    Peptide
    GHK-Cu
    Outcome
    DecreasePopulation-doubling time of irradiated fibroblasts
    Study

    humann: not reported in source

    Primary human dermal fibroblasts (normal and irradiated), serum-free medium
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 x 10(-9) mol/LAs given in this study (human).

    Source sentences

    Summary
    The population-doubling times of normal and irradiated fibroblasts exposed to GHK-Cu were faster than those of nontreated controls.
    2 context sentences
    Summary · context
    Primary human dermal fibroblast cell lines were established after explantation from intraoperative specimens obtained from patients who had undergone radiation therapy for head and neck cancer.
    Summary · context
    Treatment groups were exposed to GHK-Cu (1 x 10(-9) mol/L).
  3. 03LabIn vitro (cells)Efficacy outcome

    In irradiated fibroblasts, GHK‑Cu treatment brought the doubling rate close to that of untreated controls (the conclusion names these as normal controls); the abstract gives no statistical test for this.

    In plain wordsIn cells, irradiated fibroblasts treated with GHK‑Cu doubled at about the same rate as untreated normal control cells.

    Peptide
    GHK-Cu
    Outcome
    No significant changeDoubling rate of GHK-Cu-treated irradiated fibroblasts versus untreated controls
    Study

    humann: not reported in source

    Primary human dermal fibroblasts (normal and irradiated), serum-free medium
    Comparator
    Untreated normal fibroblast controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 x 10(-9) mol/LAs given in this study (human).

    Source sentences

    Summary
    Irradiated fibroblasts treated with GHK-Cu doubled at a rate that approximated that of untreated controls,
    2 context sentences
    Summary · context
    Primary human dermal fibroblast cell lines were established after explantation from intraoperative specimens obtained from patients who had undergone radiation therapy for head and neck cancer.
    Summary · context
    Treatment groups were exposed to GHK-Cu (1 x 10(-9) mol/L).
  4. 04LabIn vitro (cells)Efficacy outcome

    In irradiated fibroblasts, GHK‑Cu significantly increased basic fibroblast growth factor production early after exposure compared with untreated controls.

    In plain wordsIn cells, GHK‑Cu raised the early production of basic fibroblast growth factor in irradiated fibroblasts compared with untreated cells.

    Peptide
    GHK-Cu
    Outcome
    IncreaseBasic fibroblast growth factor production by irradiated fibroblasts
    Study

    humann: not reported in source

    Primary human dermal fibroblasts (normal and irradiated), serum-free medium
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 x 10(-9) mol/LAs given in this study (human).

    Source sentences

    Summary
    Irradiated fibroblasts treated with GHK-Cu doubled at a rate that approximated that of untreated controls, and produced significantly more basic fibroblast growth factor and vascular endothelial growth factor than untreated controls early after GHK-Cu exposure.
    2 context sentences
    Summary · context
    Primary human dermal fibroblast cell lines were established after explantation from intraoperative specimens obtained from patients who had undergone radiation therapy for head and neck cancer.
    Summary · context
    Treatment groups were exposed to GHK-Cu (1 x 10(-9) mol/L).
  5. 05LabIn vitro (cells)Efficacy outcome

    In irradiated fibroblasts, GHK‑Cu significantly increased vascular endothelial growth factor production early after exposure compared with untreated controls.

    In plain wordsIn cells, GHK‑Cu raised the early production of vascular endothelial growth factor in irradiated fibroblasts compared with untreated cells.

    Peptide
    GHK-Cu
    Outcome
    IncreaseVascular endothelial growth factor production by irradiated fibroblasts
    Study

    humann: not reported in source

    Primary human dermal fibroblasts (normal and irradiated), serum-free medium
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 x 10(-9) mol/LAs given in this study (human).

    Source sentences

    Summary
    Irradiated fibroblasts treated with GHK-Cu doubled at a rate that approximated that of untreated controls, and produced significantly more basic fibroblast growth factor and vascular endothelial growth factor than untreated controls early after GHK-Cu exposure.
    2 context sentences
    Summary · context
    Primary human dermal fibroblast cell lines were established after explantation from intraoperative specimens obtained from patients who had undergone radiation therapy for head and neck cancer.
    Summary · context
    Treatment groups were exposed to GHK-Cu (1 x 10(-9) mol/L).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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