In mice and rats with corticosteroid-induced muscle atrophy, activation of the VPAC2 receptor, but not VPAC1, reduced the loss of muscle mass and force.
In plain wordsIn mice and rats, a drug that activates one VIP receptor reduced muscle loss and weakness caused by a steroid.
- Outcome
- DecreaseSkeletal muscle mass and force loss, corticosteroid-induced atrophy
- Study
mice and ratsn: not reported in source
nerve damage-, corticosteroid- or disuse-induced skeletal muscle atrophy- Outcome group
- Muscle injury and repair · Musculoskeletal
Source sentences
These analyses demonstrated that activation of VPAC2R, but not VPAC1R, reduced the loss of skeletal muscle mass and force during conditions of skeletal muscle atrophy resulting from corticosteroid administration, denervation, casting-induced disuse
1 context sentence(design, population, supporting numbers)
To evaluate the function of the VPAC2R in the physiological control of skeletal muscle mass, we utilized the VPAC1R selective agonist [K15,R16,L27]VIP(1-7) GRF(8-27)-NH2 and the VPAC2R selective agonist Ro-25-1553 to treat mice and rats undergoing either nerve damage-, corticosteroid-, or disuse-ind…
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).