ACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF.

Hirotani C, Oki Y, Ukai K, Okuno T, Kurasaki S, Ohyama T, Doi N, Sasaki K, Ase K

Naunyn-Schmiedeberg's archives of pharmacology12 Jan 2005Cited by 15 (Europe PMC)

PMID15645295DOI10.1007/s00210-004-1009-3PepBankPUB-15645295

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In conscious rats, intravenous KP-102 significantly increased plasma ACTH.
In plain wordsIn rats, an intravenous KP-102 injection raised blood ACTH.
Peptide
GHRP-2
Outcome
IncreasePlasma ACTH after intravenous KP-102
Study
ratn: not reported in source
Conscious rats
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
Administration of KP-102 i.v. increased plasma ACTH significantly
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
Report a problemFND-1564529501
02LabIn vitro (cells)Activity measurement
KP-102 did not stimulate ACTH release from rat primary pituitary cells.
In plain wordsIn rat pituitary cells, KP-102 did not trigger ACTH release.
Peptide
GHRP-2
Outcome
No significant changeACTH release from primary pituitary cells
Study
ratn: not reported in source
Rat primary pituitary cells
Outcome group
Hormone levels · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
but did not stimulate ACTH release from rat primary pituitary cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
Report a problemFND-1564529502

Studies that did not test the peptide alone5

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

03AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Activity measurement
In conscious rats, KP-102 given together with AVP raised plasma ACTH significantly more than either agonist alone.
In plain wordsIn rats, KP-102 and AVP together raised blood ACTH more than either one alone.
Peptide
GHRP-2
Outcome
IncreasePlasma ACTH after KP-102 plus AVP
Study
ratn: not reported in source
Conscious rats
Comparator
Either agonist alone
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
Administration of KP-102 together with either AVP or CRF elicited significantly greater increases in plasma ACTH levels than any of the agonists alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1564529503
04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Activity measurement
In conscious rats, KP-102 given together with CRF raised plasma ACTH significantly more than either agonist alone.
In plain wordsIn rats, KP-102 and CRF together raised blood ACTH more than either one alone.
Peptide
GHRP-2
Outcome
IncreasePlasma ACTH after KP-102 plus CRF
Study
ratn: not reported in source
Conscious rats
Comparator
Either agonist alone
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
Administration of KP-102 together with either AVP or CRF elicited significantly greater increases in plasma ACTH levels than any of the agonists alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1564529504
05AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Activity measurement
In conscious rats, KP-102 plus AVP produced a much greater ACTH increase than KP-102 plus CRF.
In plain wordsIn rats, KP-102 with AVP raised blood ACTH much more than KP-102 with CRF.
Peptide
GHRP-2
Outcome
IncreasePlasma ACTH after KP-102 plus AVP versus KP-102 plus CRF
Study
ratn: not reported in source
Conscious rats
Comparator
KP-102 plus CRF
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
Notably, the combination of KP-102 and AVP produced a much greater increase in ACTH than KP-102 plus CRF, indicating that KP-102 augments the effect of exogenous CRF only weakly.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1564529505
06AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Activity measurement
In conscious rats, a CRF antagonist markedly inhibited KP-102-induced ACTH release.
In plain wordsIn rats, blocking CRF strongly reduced the ACTH release caused by KP-102.
Peptide
GHRP-2
Outcome
DecreaseKP-102-induced ACTH release with a CRF antagonist
Study
ratn: not reported in source
Conscious rats
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
a CRF antagonist markedly inhibited KP-102-induced ACTH release in conscious rats
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1564529506
07AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Activity measurement
In conscious rats, an AVP antagonist or anti-AVP antiserum did not inhibit KP-102-induced ACTH release.
In plain wordsIn rats, blocking AVP did not reduce the ACTH release caused by KP-102.
Peptide
GHRP-2
Outcome
No significant changeKP-102-induced ACTH release with an AVP antagonist or anti-AVP antiserum
Study
ratn: not reported in source
Conscious rats
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
whereas an AVP antagonist or anti-AVP antiserum did not.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, we investigated the effects of KP-102 on ACTH release in conscious rats under improved experimental conditions that minimized the influence of stress.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-1564529507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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