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Study · Animal study (in vivo) · rat · 2005

12 results

Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats.

Fukumoto K, Nagaoka I, Yamataka A, Kobayashi H, Yanai T, Kato Y, Miyano T

Pediatric surgery international1 Jan 2005Cited by 56 (Europe PMC)

PMID15645239 (opens in a new tab)DOI10.1007/s00383-004-1256-x (opens in a new tab)PepBankPUB-15645239
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, lower doses of LL‑37 given with LPS decreased mortality compared with LPS without LL‑37.

    In plain wordsIn young rats with sepsis, lower doses of LL‑37 given with LPS reduced deaths compared with LPS alone.

    Peptide
    LL-37
    Outcome
    DecreaseMortality, lower doses of LL-37 given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Mortality · Infection
    Studied dose
    lower doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    For rats receiving lower doses of LL-37 in groups 1 and 2, mortality was decreased.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, lower doses of LL‑37 given 2 h after LPS decreased mortality compared with LPS without LL‑37.

    In plain wordsIn young rats with sepsis, lower doses of LL‑37 given later reduced deaths compared with LPS alone.

    Peptide
    LL-37
    Outcome
    DecreaseMortality, lower doses of LL-37 given 2 h after LPS (group 2)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Mortality · Infection
    Studied dose
    lower doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    For rats receiving lower doses of LL-37 in groups 1 and 2, mortality was decreased.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, no deaths occurred with higher doses of LL‑37 given with LPS, while all rats given LPS without LL‑37 died.

    In plain wordsIn young rats with sepsis, no rat died with higher doses of LL‑37 given with LPS, while all rats given LPS alone died.

    Peptide
    LL-37
    Outcome
    DecreaseMortality, higher doses of LL-37 given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Mortality · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    All rats in group 3 died.
    3 context sentences
    Summary · context
    No deaths occurred among those receiving higher doses of LL-37 in group 1; however, mortality increased in group 2.
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, mortality increased in group 2 (LL‑37 given 2 h after LPS) at higher doses; the abstract does not name the comparison group.

    In plain wordsIn young rats with sepsis, higher LL‑37 doses given later were followed by increased deaths.

    Peptide
    LL-37
    Outcome
    IncreaseMortality, higher doses of LL-37 given 2 h after LPS (group 2)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Outcome group
    Mortality · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    No deaths occurred among those receiving higher doses of LL-37 in group 1; however, mortality increased in group 2.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, the overall assessment score deteriorated initially with lower doses of LL‑37 given with LPS, then improved.

    In plain wordsIn young rats with sepsis, lower LL‑37 doses given with LPS first made condition scores worse, then better.

    Peptide
    LL-37
    Outcome
    MixedOverall assessment score, lower doses given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Outcome group
    Inflammation markers · Infection
    Studied dose
    lower doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In group 1, OAS and RT deteriorated initially for those receiving lower doses of LL-37, then improved.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, rectal temperature deteriorated initially with lower doses of LL‑37 given with LPS, then improved.

    In plain wordsIn young rats with sepsis, lower LL‑37 doses given with LPS first worsened body temperature, then it improved.

    Peptide
    LL-37
    Outcome
    MixedRectal temperature, lower doses given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Outcome group
    Inflammation markers · Infection
    Studied dose
    lower doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In group 1, OAS and RT deteriorated initially for those receiving lower doses of LL-37, then improved.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, the overall assessment score did not deteriorate with higher doses of LL‑37 given with LPS.

    In plain wordsIn young rats with sepsis, condition scores did not get worse with higher LL‑37 doses given with LPS.

    Peptide
    LL-37
    Outcome
    No significant changeOverall assessment score, higher doses given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Outcome group
    Inflammation markers · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    OAS and RT did not deteriorate throughout the study in rats given higher doses of LL-37.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, rectal temperature did not deteriorate with higher doses of LL‑37 given with LPS.

    In plain wordsIn young rats with sepsis, body temperature did not get worse with higher LL‑37 doses given with LPS.

    Peptide
    LL-37
    Outcome
    No significant changeRectal temperature, higher doses given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Outcome group
    Inflammation markers · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    OAS and RT did not deteriorate throughout the study in rats given higher doses of LL-37.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, the overall assessment score with higher doses of LL‑37 given 2 h after LPS was not significantly different from LPS without LL‑37.

    In plain wordsIn young rats with sepsis, higher LL‑37 doses given later did not change condition scores compared with LPS alone.

    Peptide
    LL-37
    Outcome
    No significant changeOverall assessment score, higher doses given 2 h after LPS (group 2)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Inflammation markers · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In group 2 rats given higher doses of LL-37, OAS and RT were not significantly different from rats in group 3.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, rectal temperature with higher doses of LL‑37 given 2 h after LPS was not significantly different from LPS without LL‑37.

    In plain wordsIn young rats with sepsis, higher LL‑37 doses given later did not change body temperature compared with LPS alone.

    Peptide
    LL-37
    Outcome
    No significant changeRectal temperature, higher doses given 2 h after LPS (group 2)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Inflammation markers · Infection
    Studied dose
    higher doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In group 2 rats given higher doses of LL-37, OAS and RT were not significantly different from rats in group 3.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, serum CRP was significantly decreased with LL‑37 given with LPS compared with LPS without LL‑37.

    In plain wordsIn young rats with sepsis, LL‑37 given with LPS lowered the blood inflammation marker CRP compared with LPS alone.

    Peptide
    LL-37
    Outcome
    DecreaseSerum C-reactive protein, LL-37 given with LPS (group 1)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Inflammation markers · Infection
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    CRP was significantly decreased in group 1 compared with group 3, and decreased in group 2 for lower doses only.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In neonatal rats with LPS-induced sepsis, serum CRP decreased with lower doses of LL‑37 given 2 h after LPS, but not with higher doses.

    In plain wordsIn young rats with sepsis, only lower LL‑37 doses given later reduced the blood inflammation marker CRP.

    Peptide
    LL-37
    Outcome
    DecreaseSerum C-reactive protein, lower doses given 2 h after LPS (group 2)
    Study

    ratn: not reported in source

    LPS-induced sepsis in suckling (neonatal) rats
    Comparator
    Group 3 (LPS without LL-37)
    Outcome group
    Inflammation markers · Infection
    Studied dose
    lower doses · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    CRP was significantly decreased in group 1 compared with group 3, and decreased in group 2 for lower doses only.
    2 context sentences
    Summary · context
    Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats.
    Summary · context
    Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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