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Study · Animal study (in vivo) · rat · 2004

9 results

[Effect of thymosin alpha1 on immunological function and metabolism in peritoneal sepsis rats].

Jiang J, Li N, Li JS

Zhonghua wai ke za zhi [Chinese journal of surgery]1 Nov 2004Cited by 1 (Europe PMC)

PMID15634408 (opens in a new tab)PepBankPUB-15634408
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly decreased TNF-alpha.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 lowered TNF-alpha, an inflammation signal, compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTNF-alpha concentration
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly decreased IL-6.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 lowered IL-6, an inflammation signal, compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-6 concentration
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly raised plasma IL-10.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 raised plasma IL-10 compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePlasma IL-10 concentration
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly raised the percentage of CD3 cells.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 raised the share of CD3 immune cells compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD3 T cell percentage
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly raised the percentage of CD4 cells.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 raised the share of CD4 immune cells compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4 T cell percentage
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 significantly raised the CD4/CD8 value.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 raised the CD4/CD8 immune cell ratio compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4/CD8 ratio
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 reduced the fall in albumin.

    In plain wordsIn rats with sepsis, thymosin alpha‑1 lessened the drop in albumin compared with untreated septic rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseAlbumin decline
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 reduced degressive degree of albumin.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, CRP rose in both septic groups but less in the thymosin alpha‑1 treated group.

    In plain wordsIn rats with sepsis, CRP rose in all septic groups but rose less with thymosin alpha‑1 than without it.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseC-reactive protein concentration
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Concentration of CRP increased in both septic groups, but was less prominently in thymosin alpha1 treated group.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cecal ligation and puncture sepsis, thymosin alpha‑1 reduced cumulative 7-day mortality.

    In plain wordsIn rats with sepsis, fewer rats died within 7 days with thymosin alpha‑1 than without it.

    Peptide
    Thymosin alpha-1
    Outcome
    Decrease7-day cumulative mortality
    Study

    ratn: not reported in source

    Cecal ligation and puncture (CLP) induced peritoneal sepsis
    Comparator
    Untreated septic group
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin alpha1 reduced cumulate 7-day mortality.
    1 context sentence
    Summary · context
    We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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